![CAS 2377354-94-2 tert-butyl 4-fluoro-1-oxo-1,3-dihydrospiro[indene-2,4′-piperidine]-1′-carboxylate molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/2377354-94-2.gif)
CAS RN: 2377354-94-2
tert-butyl 4-fluoro-1-oxo-1,3-dihydrospiro[indene-2,4′-piperidine]-1′-carboxylate
Product Availability
Choose a grade to view its available package options.
1 package records1 with current stock1 grade group
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20251019 | 100mg / 250mg | Confirm by inquiry | Shanghai | Inquiry |
- Product code: SSC-115641
Historical Factory Record
Historical Supply Reference
This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.
- Pack sizes on record: 1g
- Available purity: ＞97%
- Inventory rows with stock: 0
- Bulk packaging: confirmed by inquiry
Reference Pack Sizes
Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.
| Pack Size | Recorded Purity | Available Qty | Ship From | Inquiry |
|---|---|---|---|---|
| 1g | ＞97% | 0 Out of Stock | Shanghai | Inquiry |
2377354-94-2 / tert-butyl 7-fluoro-3-oxospiro[1H-indene-2,4'-piperidine]-1'-carboxylate
Basic Information
CAS
2377354-94-2
Multi CAS
No
Molecular Formula
C18H22FNO3
Molecular Weight
319.400000
Exact Mass
319.158372
SMILES
CC(C)(C)OC(=O)N1CCC2(CC1)CC3=C(C2=O)C=CC=C3F
InChI
InChI=1S/C18H22FNO3/c1-17(2,3)23-16(22)20-9-7-18(8-10-20)11-13-12(15(18)21)5-4-6-14(13)19/h4-6H,7-11H2,1-3H3
InChIKey
ULMUUCXCIASVEH-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
23
Aromatic heavy atom count
6
Fraction Csp3
0.56
Rotatable bonds
2
H-bond acceptors
3
Molar refractivity
83.91
TPSA
46.61
LogP / Solubility
WLOGP
3.58
MLOGP
3.17
XLogP3
3
Consensus LogP
3.25
Log S (ESOL)
-4.27
Class (ESOL)
Slightly soluble
Log S (Ali)
-4.76
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-4.71
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-2.13
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3.5
Customers Also Viewed
-
![CAS 2377355-25-2 Spiro[2H-indene-2,4′-piperidine]-1′-carboxylic acid, 5-bromo-3-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-1,3-dihydro-, 1,1-dimethylethyl ester, (3S)- molecular structure](data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E)
Spiro[2H-indene-2,4′-piperidine]-1′-carboxylic acid, 5-bromo-3-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-1,3-dihydro-, 1,1-dimethylethyl ester, (3S)-
- CAS RN: 2377355-25-2
- Product Code: SSC-115644
-
Spiro[6H-cyclopenta[b]pyridine-6,4′-piperidin]-5-amine, 5,7-dihydro-, hydrochloride (1:2), (5S)-
- CAS RN: 2377355-48-9
- Product Code: SSC-115646
-
-
MRGPRX1 agonist 1
- CAS RN: 2377379-39-8
- Product Code: starshine_CAS2377379-39-8
- Purity/Analytical method: >99.0%
-
-
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-
- CAS RN: 2377491-54-6
- Product Code: SSC-115663
![CAS 2377355-25-2 Spiro[2H-indene-2,4′-piperidine]-1′-carboxylic acid, 5-bromo-3-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-1,3-dihydro-, 1,1-dimethylethyl ester, (3S)- molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/2377355-25-2.gif)
![CAS 2377355-48-9 Spiro[6H-cyclopenta[b]pyridine-6,4′-piperidin]-5-amine, 5,7-dihydro-, hydrochloride (1:2), (5S)- molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/2377355-48-9.gif)
![CAS 2377491-54-6 Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/2377491-54-6.gif)