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CAS 2377491-54-6 Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- molecular structure lightbox
CAS RN: 2377491-54-6

Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-

Product Availability

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8 package records6 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250614 100mg In stock Shanghai Inquiry
Batchno.20250529 10mg In stock Shanghai Inquiry
Batchno.20260518 1mg In stock Shanghai Inquiry
Batchno.20250423 250mg Out of stock Inquiry
Batchno.20251007 25mg In stock Shanghai Inquiry
Batchno.20251130 25mg / 50mg / 100mg Out of stock 8-10 business days Inquiry
Batchno.20260624 50mg In stock Shanghai Inquiry
Batchno.20250330 5mg In stock Shanghai Inquiry
  • Product code: SSC-115663
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 2377491-54-6
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Beijing Inquiry

2377491-54-6 / 8-(4-chlorophenyl)-6-(2-methylindazol-5-yl)-2-(2,2,2-trifluoroethylamino)pyrido[4,3-d]pyrimidin-7-one

Standard CAS: 2377491-54-6 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
2377491-54-6
Multi CAS
No
Molecular Formula
C23H16ClF3N6O
Molecular Weight
484.900000
Exact Mass
484.102621
SMILES
CN1C=C2C=C(C=CC2=N1)N3C=C4C=NC(=NC4=C(C3=O)C5=CC=C(C=C5)Cl)NCC(F)(F)F
InChI
InChI=1S/C23H16ClF3N6O/c1-32-10-14-8-17(6-7-18(14)31-32)33-11-15-9-28-22(29-12-23(25,26)27)30-20(15)19(21(33)34)13-2-4-16(24)5-3-13/h2-11H,12H2,1H3,(H,29,30)
InChIKey
XXCYDSDPIJJBSI-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
34
Aromatic heavy atom count
25
Fraction Csp3
0.13
Rotatable bonds
4
H-bond acceptors
7
H-bond donors
1
Molar refractivity
124.4
TPSA
77.63

LogP / Solubility

WLOGP
4.96
MLOGP
4.4
XLogP3
3.3
Consensus LogP
4.22
Log S (ESOL)
-6.25
Class (ESOL)
Insoluble
Log S (Ali)
-7.12
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.41
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.15

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3.5

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