![CAS 1445379-61-2 Uridine, 2′-deoxy-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-2′-fluoro-4′-C-(hydroxymethyl)- molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1445379-61-2.gif)
CAS RN: 1445379-61-2
Uridine, 2′-deoxy-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-2′-fluoro-4′-C-(hydroxymethyl)-
Product Availability
Choose a grade to view its available package options.
1 package records0 with current stock1 grade group
| Batch No. | Package | Availability | Lead Time | Inquiry |
|---|---|---|---|---|
| Batchno.20260228 | 100mg | Out of stock | 8-10 business days | Inquiry |
- Product code: starshine_CAS1445379-61-2
- Purity/Analytical Methods: >99.0%
1445379-61-2 / 1-[(2R,3R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-3-fluoro-5,5-bis(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Basic Information
CAS
1445379-61-2
Multi CAS
No
Molecular Formula
C16H27FN2O6Si
Molecular Weight
390.480000
Exact Mass
390.162241
SMILES
CC(C)(C)[Si](C)(C)O[C@H]1[C@H]([C@@H](OC1(CO)CO)N2C=CC(=O)NC2=O)F
InChI
InChI=1S/C16H27FN2O6Si/c1-15(2,3)26(4,5)25-12-11(17)13(24-16(12,8-20)9-21)19-7-6-10(22)18-14(19)23/h6-7,11-13,20-21H,8-9H2,1-5H3,(H,18,22,23)/t11-,12+,13-/m1/s1
InChIKey
FQCJMRIFHYTBRI-FRRDWIJNSA-N
Computed Properties
Structural Parameters
Heavy atom count
26
Aromatic heavy atom count
6
Fraction Csp3
0.75
Rotatable bonds
5
H-bond acceptors
7
H-bond donors
3
Molar refractivity
95.31
TPSA
113.78
LogP / Solubility
WLOGP
0.52
MLOGP
0.48
XLogP3
0.52
Consensus LogP
0.51
Log S (ESOL)
-2.43
Class (ESOL)
Moderately soluble
Log S (Ali)
-3.14
Class (Ali)
Poorly soluble
Log S (SILICOS-IT)
-3.23
Class (SILICOS-IT)
Poorly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-4.73
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
4
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