[email protected]
CAS 1448867-41-1 Siremadlin molecular structure lightbox
CAS RN: 1448867-41-1

Siremadlin

Product Availability

Choose a grade to view its available package options.

12 package records8 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250617 100mg In stock Inquiry
Batchno.20251203 10mg In stock Inquiry
Batchno.20260317 1mg In stock Inquiry
Batchno.20251217 25mg In stock Inquiry
Batchno.20260610 50mg In stock Inquiry
Batchno.20250819 5mg In stock Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260206 100mg Out of stock Inquiry
Batchno.20250418 1g Out of stock Inquiry
Batchno.20260522 1mg In stock Shanghai Inquiry
Batchno.20260208 250mg Out of stock Inquiry
Batchno.20260618 50mg In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20251009 1mg / 5mg Out of stock 5-7 business days Inquiry
  • Product code: SSC-056244
GET A QUOTE
Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
Request Bulk Quote

Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1448867-41-1
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Hong Kong Inquiry

1448867-41-1 / (4S)-5-(5-chloro-1-methyl-2-oxo-3-pyridinyl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one

Standard CAS: 1448867-41-1 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
1448867-41-1
Multi CAS
No
Molecular Formula
C26H24Cl2N6O4
Molecular Weight
555.400000
Exact Mass
554.123609
SMILES
CC(C)N1C2=C(C(=O)N([C@H]2C3=CC=C(C=C3)Cl)C4=CC(=CN(C4=O)C)Cl)N=C1C5=CN=C(N=C5OC)OC
InChI
InChI=1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18)35)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3/t20-/m0/s1
InChIKey
AGBSXNCBIWWLHD-FQEVSTJZSA-N

Computed Properties

Structural Parameters

Heavy atom count
38
Aromatic heavy atom count
23
Fraction Csp3
0.27
Rotatable bonds
6
H-bond acceptors
9
Molar refractivity
143.54
TPSA
104.37

LogP / Solubility

WLOGP
4.69
MLOGP
4.17
XLogP3
3.6
Consensus LogP
4.15
Log S (ESOL)
-6.29
Class (ESOL)
Insoluble
Log S (Ali)
-7.5
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.89
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.78

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
5.5

Customers Also Viewed

Get In Touch

Contact Us