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CAS 80-08-0 Bis(4-aminophenyl) Sulfone molecular structure lightbox
CAS RN: 80-08-0

Bis(4-aminophenyl) Sulfone

Product Availability

Choose a grade to view its available package options.

10 package records9 with current stock5 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250720 100g / 500g / 2.5kg / 10kg Confirm by inquiry Shanghai, Shandong, Guangdong, Hebei Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260628 50g / 100g / 500g / 1kg / 2.5kg Confirm by inquiry Shanghai, Shandong, Guangdong, Chongqing, Hebei Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260401 500g Out of stock 15 business days Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260207 100g In stock Shanghai, Shenzhen, Tianjin, Wuhan, Chengdu Inquiry
Batchno.20260223 1kg In stock Shanghai, Wuhan, Chengdu Inquiry
Batchno.20251215 25g In stock Shanghai, Tianjin Inquiry
Batchno.20251224 500g In stock Shanghai, Shenzhen, Tianjin, Wuhan Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250405 250g In stock Inquiry
Batchno.20250629 50g In stock Inquiry
Batchno.20250805 5g In stock Inquiry
  • Product code: SSC-188988
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 500g
  • Available purity: ＞97%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 80-08-0
Pack Size Recorded Purity Available Qty Ship From Inquiry
500g ＞97% 0 Out of Stock Shanghai Inquiry

80-08-0 / 4-(4-aminophenyl)sulfonylaniline

Standard CAS: 80-08-0 Multi CAS: Yes
Basic Information Physical Properties Computed Properties

Basic Information

CAS
80-08-0
Multi CAS
Yes
Molecular Formula
C12H12N2O2S
Molecular Weight
248.300000
Exact Mass
248.061949
InChI
InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
InChIKey
MQJKPEGWNLWLTK-UHFFFAOYSA-N

Physical Properties

Melting Point
347 to 349 °F (NTP, 1992) 175-176 °C (also a higher melting form, MP 180.5 °C) There are extraordinarily complicated polymorphism conditions in the drugs dapsone and ethambutol chloride. In both cases, four modifications were detected, and in the case of dapsone there exists a hydrate in addition. The dapsone anhydrate is present as enantiotropic Mod. III, which transforms into Mod. II at 80 °C. This form is mostly stable up to its melting point. Mod. I, which crystallizes from the melt, is likewise enantiotropic with Mod. II. In addition, there is enantiotropy between Mod. I and Mod. III. The transformation of Mod. III /between/ Mod. II takes place continuously and independently from nuclei, so that the melting point of Mod. III cannot be determined. In Mod. IV, no enantiotropy with another crystal form could be detected. ... 175.5 °C
Density
1.33 at 77 °F (NTP, 1992) - Denser than water; will sink
Physical Description
4,4'-sulfonyldianiline appears as odorless white or creamy white crystalline powder. Slightly bitter taste. (NTP, 1992) Pellets or Large Crystals Odorless white or creamy white crystalline powder; [CAMEO] Solid
Appearance
Crystals from 95% ethanol White or creamy white crystalline powder
State
Solid

Computed Properties

Structural Parameters

Heavy atom count
17
Aromatic heavy atom count
12
Rotatable bonds
2
H-bond acceptors
4
H-bond donors
2
Molar refractivity
67.16
TPSA
86.18

LogP / Solubility

WLOGP
1.68
MLOGP
1.49
XLogP3
1
Consensus LogP
1.39
Log S (ESOL)
-2.83
Class (ESOL)
Moderately soluble
Log S (Ali)
-2.81
Class (Ali)
Moderately soluble
Log S (SILICOS-IT)
-2.91
Class (SILICOS-IT)
Moderately soluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-3.04

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
1.5

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