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CAS 64-77-7 Tolbutamide molecular structure lightbox
CAS RN: 64-77-7

Tolbutamide

Product Availability

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6 package records6 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20251009 1g / 5g / 25g / 100g Confirm by inquiry Shanghai, Shandong, Guangdong, Chongqing, Hebei Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260421 100g In stock Shanghai Inquiry
Batchno.20260313 1g In stock Shanghai, Shenzhen, Chengdu Inquiry
Batchno.20250315 25g In stock Shanghai Inquiry
Batchno.20260324 500g In stock Shanghai Inquiry
Batchno.20260219 5g In stock Shanghai Inquiry
  • Product code: SSC-173785
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 100g
  • Available purity: ＞97%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 64-77-7
Pack Size Recorded Purity Available Qty Ship From Inquiry
100g ＞97% 0 Out of Stock Shenzhen Inquiry

64-77-7 / 1-butyl-3-(4-methylphenyl)sulfonylurea

Standard CAS: 64-77-7 Multi CAS: Yes
Basic Information Physical Properties Computed Properties

Basic Information

CAS
64-77-7
Multi CAS
Yes
Molecular Formula
C12H18N2O3S
Molecular Weight
270.350000
Exact Mass
270.103814
InChI
InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChIKey
JLRGJRBPOGGCBT-UHFFFAOYSA-N

Physical Properties

Melting Point
262 to 264 °F (NTP, 1992) 128.5-129.5 °C MP: 41-43 °C; when anhyd, mp range is 130-133 °C /Sodium salt tetrahydrate/ 128.5 °C
Density
1.245 at 77 °F (NTP, 1992) - Denser than water; will sink 1.245 g/cu cm @ 25 °C
Physical Description
Tolbutamide appears as white crystals. (NTP, 1992) Solid
Appearance
WHITE OR PRACTICALLY WHITE CRYSTALLINE POWDER Crystals
State
Solid

Computed Properties

Structural Parameters

Heavy atom count
18
Aromatic heavy atom count
6
Fraction Csp3
0.42
Rotatable bonds
5
H-bond acceptors
3
H-bond donors
2
Molar refractivity
69.81
TPSA
75.27

LogP / Solubility

WLOGP
1.78
MLOGP
1.58
XLogP3
2.3
Consensus LogP
1.89
Log S (ESOL)
-2.56
Class (ESOL)
Moderately soluble
Log S (Ali)
-3.06
Class (Ali)
Poorly soluble
Log S (SILICOS-IT)
-3.5
Class (SILICOS-IT)
Poorly soluble

ADME

GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-3.1

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
Yes
Synthetic Accessibility
1.5

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