CAS RN: 58-14-0
Pyrimethamine
Product Availability
Choose a grade to view its available package options.
7 package records6 with current stock1 grade group
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20251010 | 100g | In stock | Tianjin, Chengdu | Inquiry |
| Batchno.20251201 | 10g | In stock | Shanghai, Wuhan, Chengdu | Inquiry |
| Batchno.20250708 | 1g | In stock | Shanghai, Tianjin, Chengdu | Inquiry |
| Batchno.20251127 | 250mg | In stock | Shanghai, Tianjin | Inquiry |
| Batchno.20250622 | 25g | In stock | Shanghai, Wuhan, Chengdu | Inquiry |
| Batchno.20250208 | 500g | Out of stock | Inquiry | |
| Batchno.20250322 | 5g | In stock | Shanghai, Shenzhen | Inquiry |
- Product code: SSC-166188
Historical Factory Record
Historical Supply Reference
This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.
- Pack sizes on record: 10g
- Available purity: ≥95%
- Inventory rows with stock: 0
- Bulk packaging: confirmed by inquiry
Reference Pack Sizes
Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.
| Pack Size | Recorded Purity | Available Qty | Ship From | Inquiry |
|---|---|---|---|---|
| 10g | ≥95% | 0 Out of Stock | Beijing | Inquiry |
58-14-0 / 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
Basic Information
CAS
58-14-0
Multi CAS
Yes
Molecular Formula
C12H13CLN4
Molecular Weight
248.710000
Exact Mass
248.082874
InChI
InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)
InChIKey
WKSAUQYGYAYLPV-UHFFFAOYSA-N
Physical Properties
Melting Point
451 to 453 °F (capillary) (NTP, 1992)
233-234 °C (capillary); 240-242 °C (copper block)
233.5 °C
Physical Description
Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.
Solid
Appearance
Crystals
White scored tablets contains 25 mg pyrimethamine /Daraprim/
State
Solid
Computed Properties
Structural Parameters
Heavy atom count
17
Aromatic heavy atom count
12
Fraction Csp3
0.17
Rotatable bonds
2
H-bond acceptors
4
H-bond donors
2
Molar refractivity
70.68
TPSA
77.82
LogP / Solubility
WLOGP
2.52
MLOGP
2.23
XLogP3
2.7
Consensus LogP
2.48
Log S (ESOL)
-3.36
Class (ESOL)
Poorly soluble
Log S (Ali)
-3.42
Class (Ali)
Poorly soluble
Log S (SILICOS-IT)
-3.61
Class (SILICOS-IT)
Poorly soluble
ADME
GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-2.45
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
1.5
