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CAS 475108-18-0 Tivozanib molecular structure lightbox
CAS RN: 475108-18-0

Tivozanib

Product Availability

Choose a grade to view its available package options.

8 package records8 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260130 5mg / 25mg / 100mg Confirm by inquiry Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250215 100mg In stock Shanghai, Shenzhen Inquiry
Batchno.20251220 1g In stock Shenzhen Inquiry
Batchno.20260213 1mg In stock Shanghai Inquiry
Batchno.20250811 250mg In stock Shanghai Inquiry
Batchno.20250423 50mg In stock Shanghai Inquiry
Batchno.20250412 5mg In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250709 5mg / 25mg / 100mg Confirm by inquiry Shanghai, Shandong Inquiry
  • Product code: SSC-154488
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 475108-18-0
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Beijing Inquiry

475108-18-0 / 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea

Standard CAS: 475108-18-0 Multi CAS: Yes
Basic Information Physical Properties Computed Properties

Basic Information

CAS
475108-18-0
Multi CAS
Yes
Molecular Formula
C22H19CLN4O5
Molecular Weight
454.900000
Exact Mass
454.104397
InChI
InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
InChIKey
SPMVMDHWKHCIDT-UHFFFAOYSA-N

Physical Properties

Melting Point
220-233

Computed Properties

Structural Parameters

Heavy atom count
32
Aromatic heavy atom count
21
Fraction Csp3
0.14
Rotatable bonds
6
H-bond acceptors
7
H-bond donors
2
Molar refractivity
120.25
TPSA
107.74

LogP / Solubility

WLOGP
5.64
MLOGP
4.99
XLogP3
4
Consensus LogP
4.88
Log S (ESOL)
-6.3
Class (ESOL)
Insoluble
Log S (Ali)
-7.36
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.02
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.49

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3

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