CAS RN: 388082-78-8
Lapatinib ditosylate
Product Availability
Choose a grade to view its available package options.
10 package records9 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250603 | 10mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20260411 | 1g | In stock | Shanghai, Shenzhen | Inquiry |
| Batchno.20260320 | 1mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20260215 | 250mg | In stock | Shanghai | Inquiry |
| Batchno.20250402 | 25g | Out of stock | Inquiry | |
| Batchno.20260405 | 25mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20250814 | 50mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20250531 | 5g | In stock | Shanghai | Inquiry |
- Product code: starshine_CAS388082-78-8
- Purity/Analytical Methods: >99.0%
388082-78-8 / benzenesulfonic acid;N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;hydrate
Basic Information
CAS
388082-78-8
Multi CAS
Yes
Molecular Formula
C41H40CLFN4O11S3
Molecular Weight
915.400000
Exact Mass
914.152828
InChI
InChI=1S/C29H26ClFN4O4S.2C6H6O3S.H2O/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*7-10(8,9)6-4-2-1-3-5-6;/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*1-5H,(H,7,8,9);1H2
InChIKey
CJCNEWWARIPAEG-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
61
Aromatic heavy atom count
39
Fraction Csp3
0.12
Rotatable bonds
13
H-bond acceptors
12
H-bond donors
4
Molar refractivity
230.25
TPSA
246.59
LogP / Solubility
WLOGP
7.18
MLOGP
6.41
XLogP3
7.18
Consensus LogP
6.92
Log S (ESOL)
-9.65
Class (ESOL)
Insoluble
Log S (Ali)
-12.25
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-13.13
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.21
Drug-likeness / Medicinal Chemistry
Lipinski
No
Ghose
No
Veber
No
Egan
No
Muegge
No
Bioavailability score
0.17
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
6
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