CAS RN: 388082-77-7
Lapatinib ditosylate
Product Availability
Choose a grade to view its available package options.
8 package records7 with current stock1 grade group
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250415 | 100mg | In stock | Shanghai | Inquiry |
| Batchno.20250704 | 10mg | In stock | Shanghai | Inquiry |
| Batchno.20250124 | 1g | In stock | Shanghai, Wuhan, Chengdu | Inquiry |
| Batchno.20250303 | 1mg | In stock | Shanghai | Inquiry |
| Batchno.20250115 | 250mg | In stock | Shanghai | Inquiry |
| Batchno.20260210 | 25g | Out of stock | Inquiry | |
| Batchno.20250528 | 50mg | In stock | Shanghai, Tianjin | Inquiry |
| Batchno.20260119 | 5g | In stock | Shanghai, Shenzhen, Tianjin, Wuhan, Chengdu | Inquiry |
- Product code: LINL843988
388082-77-7 / N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;bis(4-methylbenzenesulfonic acid)
Basic Information
CAS
388082-77-7
Multi CAS
Yes
Molecular Formula
C43H42CLFN4O10S3
Molecular Weight
925.500000
Exact Mass
924.173563
InChI
InChI=1S/C29H26ClFN4O4S.2C7H8O3S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19;2*1-6-2-4-7(5-3-6)11(8,9)10/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35);2*2-5H,1H3,(H,8,9,10)
InChIKey
UWYXLGUQQFPJRI-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
62
Aromatic heavy atom count
39
Fraction Csp3
0.16
Rotatable bonds
13
H-bond acceptors
12
H-bond donors
4
Molar refractivity
236.11
TPSA
215.09
LogP / Solubility
WLOGP
8.62
MLOGP
7.67
XLogP3
8.62
Consensus LogP
8.3
Log S (ESOL)
-10.62
Class (ESOL)
Insoluble
Log S (Ali)
-13.37
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-14.39
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.24
Drug-likeness / Medicinal Chemistry
Lipinski
No
Ghose
No
Veber
No
Egan
No
Muegge
No
Bioavailability score
0.17
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
6
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- CAS RN: 476493-68-2
- Product Code: LIND889701
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