CAS RN: 284461-73-0
Sorafenib
Product Availability
Choose a grade to view its available package options.
6 package records5 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20251103 | 50mg / 100mg / 1g / 5g / 25g / 100g | Confirm by inquiry | Shandong, Shanghai, Guangdong, Chongqing, Hebei | Inquiry |
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250312 | 100g | In stock | Shanghai | Inquiry |
| Batchno.20250131 | 1g | In stock | Shanghai, Shenzhen, Tianjin, Wuhan, Chengdu | Inquiry |
| Batchno.20260603 | 25g | In stock | Shanghai, Shenzhen | Inquiry |
| Batchno.20260130 | 500g | Out of stock | Inquiry | |
| Batchno.20260326 | 5g | In stock | Shanghai, Shenzhen, Tianjin | Inquiry |
- Product code: ICTO0599
- Purity/Analytical Methods: >98.0%(T)(HPLC)
284461-73-0 / 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
Basic Information
CAS
284461-73-0
Multi CAS
Yes
Molecular Formula
C21H16CLF3N4O3
Molecular Weight
464.800000
Exact Mass
464.086303
InChI
InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
InChIKey
MLDQJTXFUGDVEO-UHFFFAOYSA-N
Physical Properties
Melting Point
187-226
205.6 °C
Physical Description
Solid
Appearance
White solid
State
Solid
Computed Properties
Structural Parameters
Heavy atom count
32
Aromatic heavy atom count
18
Fraction Csp3
0.1
Rotatable bonds
5
H-bond acceptors
4
H-bond donors
3
Molar refractivity
113.24
TPSA
92.35
LogP / Solubility
WLOGP
5.55
MLOGP
4.92
XLogP3
4.1
Consensus LogP
4.86
Log S (ESOL)
-6.3
Class (ESOL)
Insoluble
Log S (Ali)
-7.38
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.89
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.62
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
2.5
![CAS 2840-35-9 [1,1′-Biphenyl]-3-carboxylicacid, 4-methyl- molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/2840-35-9.gif)