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CAS 231277-92-2 Lapatinib molecular structure lightbox
CAS RN: 231277-92-2

Lapatinib

Product Availability

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6 package records4 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250306 100mg Out of stock Inquiry
Batchno.20251204 1g In stock Shenzhen Inquiry
Batchno.20260113 1mg In stock Shanghai, Wuhan Inquiry
Batchno.20250806 250mg In stock Shanghai Inquiry
Batchno.20250119 25g In stock Shenzhen Inquiry
Batchno.20250111 5g Out of stock Inquiry
  • Product code: SSC-112614
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 1g
  • Available purity: >97%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 231277-92-2
Pack Size Recorded Purity Available Qty Ship From Inquiry
1g >97% 0 Out of Stock Shanghai Inquiry

231277-92-2 / N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine

Standard CAS: 231277-92-2 Multi CAS: No
Basic Information Physical Properties Computed Properties

Basic Information

CAS
231277-92-2
Multi CAS
No
Molecular Formula
C29H26ClFN4O4S
Molecular Weight
581.100000
Exact Mass
580.134732
SMILES
CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
InChI
InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
InChIKey
BCFGMOOMADDAQU-UHFFFAOYSA-N

Physical Properties

Physical Description
Solid
State
Solid

Computed Properties

Structural Parameters

Heavy atom count
40
Aromatic heavy atom count
27
Fraction Csp3
0.17
Rotatable bonds
11
H-bond acceptors
8
H-bond donors
2
Molar refractivity
154.12
TPSA
106.35

LogP / Solubility

WLOGP
6.14
MLOGP
5.45
XLogP3
5.1
Consensus LogP
5.56
Log S (ESOL)
-7.08
Class (ESOL)
Insoluble
Log S (Ali)
-8.76
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-9.85
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.91

Drug-likeness / Medicinal Chemistry

Lipinski
No
Ghose
No
Veber
No
Egan
No
Muegge
No
Bioavailability score
0.17
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
5

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