![CAS 18037-10-0 N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/18037-10-0.gif)
CAS RN: 18037-10-0
N-(Trimethylsilyl)-2-[(trimethylsilyl)oxy]pyrimidin-4-amine
Product Availability
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1 package records0 with current stock1 grade group
| Batch No. | Package | Availability | Lead Time | Inquiry |
|---|---|---|---|---|
| Batchno.20250310 | 5g | Out of stock | 15 business days | Inquiry |
- Product code: starshine_CAS18037-10-0
- Purity/Analytical Methods: >99.0%
18037-10-0 / N-trimethylsilyl-2-trimethylsilyloxypyrimidin-4-amine
Basic Information
CAS
18037-10-0
Multi CAS
No
Molecular Formula
C10H21N3OSi2
Molecular Weight
255.460000
Exact Mass
255.122315
SMILES
C[Si](C)(C)NC1=NC(=NC=C1)O[Si](C)(C)C
InChI
InChI=1S/C10H21N3OSi2/c1-15(2,3)13-9-7-8-11-10(12-9)14-16(4,5)6/h7-8H,1-6H3,(H,11,12,13)
InChIKey
IWEHUWMQLZFGLL-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
16
Aromatic heavy atom count
6
Fraction Csp3
0.6
Rotatable bonds
4
H-bond acceptors
4
H-bond donors
1
Molar refractivity
72.97
TPSA
47.04
LogP / Solubility
WLOGP
2.94
MLOGP
2.59
XLogP3
2.94
Consensus LogP
2.82
Log S (ESOL)
-3.29
Class (ESOL)
Poorly soluble
Log S (Ali)
-3.78
Class (Ali)
Poorly soluble
Log S (SILICOS-IT)
-4.24
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-2.19
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
Yes
Synthetic Accessibility
1.5
Safety & Transport
Pictogram(s)
Corrosive
Signal
Danger
GHS Hazard Statements
H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
Precautionary Statement Codes
P264+P265, P280, P305+P354+P338, and P317
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