CAS RN: 177036-94-1
Ambrisentan
Product Availability
Choose a grade to view its available package options.
14 package records13 with current stock3 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250427 | 100mg | In stock | Shanghai, Shenzhen | Inquiry |
| Batchno.20260524 | 10mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20251217 | 1g | In stock | Shanghai | Inquiry |
| Batchno.20260622 | 1mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20260210 | 250mg | In stock | Shanghai | Inquiry |
| Batchno.20251027 | 50mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20260406 | 5g | Out of stock | Inquiry | |
| Batchno.20260109 | 5mg | In stock | Shanghai, Wuhan | Inquiry |
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250718 | 1ml | In stock | Inquiry |
- Product code: SSC-077432
Historical Factory Record
Historical Supply Reference
This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.
- Pack sizes on record: 1g
- Available purity: ≥98%
- Inventory rows with stock: 0
- Bulk packaging: confirmed by inquiry
Reference Pack Sizes
Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.
| Pack Size | Recorded Purity | Available Qty | Ship From | Inquiry |
|---|---|---|---|---|
| 1g | ≥98% | 0 Out of Stock | Shenzhen | Inquiry |
177036-94-1 / (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
Basic Information
CAS
177036-94-1
Multi CAS
No
Molecular Formula
C22H22N2O4
Molecular Weight
378.400000
Exact Mass
378.157957
SMILES
CC1=CC(=NC(=N1)O[C@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChI
InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChIKey
OUJTZYPIHDYQMC-LJQANCHMSA-N
Physical Properties
Melting Point
165-168 °C
Computed Properties
Structural Parameters
Heavy atom count
28
Aromatic heavy atom count
18
Fraction Csp3
0.23
Rotatable bonds
7
H-bond acceptors
5
H-bond donors
1
Molar refractivity
104.23
TPSA
81.54
LogP / Solubility
WLOGP
3.52
MLOGP
3.12
XLogP3
3.8
Consensus LogP
3.48
Log S (ESOL)
-4.41
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.2
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.88
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.53
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3
Safety & Transport
Pictogram(s)
Health Hazard
Signal
Danger
GHS Hazard Statements
H351 (33.3%): Suspected of causing cancer [Warning Carcinogenicity]
H360FD (66.7%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]
H361 (33.3%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H372 (33.3%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
Precautionary Statement Codes
P203, P260, P264, P270, P280, P318, P319, P405, and P501
