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CAS 145733-36-4 Tasosartan molecular structure lightbox
CAS RN: 145733-36-4

Tasosartan

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1 package records1 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260106 5mg / 10mg / 50mg Confirm by inquiry Shanghai 5-7 business days Inquiry
  • Product code: starshine_CAS145733-36-4
  • Purity/Analytical Methods: >99.0%
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145733-36-4 / 2,4-dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one

Standard CAS: 145733-36-4 Multi CAS: No
Basic Information Physical Properties Computed Properties

Basic Information

CAS
145733-36-4
Multi CAS
No
Molecular Formula
C23H21N7O
Molecular Weight
411.500000
Exact Mass
411.180758
SMILES
CC1=C2CCC(=O)N(C2=NC(=N1)C)CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5
InChI
InChI=1S/C23H21N7O/c1-14-18-11-12-21(31)30(23(18)25-15(2)24-14)13-16-7-9-17(10-8-16)19-5-3-4-6-20(19)22-26-28-29-27-22/h3-10H,11-13H2,1-2H3,(H,26,27,28,29)
InChIKey
ADXGNEYLLLSOAR-UHFFFAOYSA-N

Physical Properties

Physical Description
Solid
State
Solid

Computed Properties

Structural Parameters

Heavy atom count
31
Aromatic heavy atom count
23
Fraction Csp3
0.22
Rotatable bonds
4
H-bond acceptors
6
H-bond donors
1
Molar refractivity
116.07
TPSA
100.55

LogP / Solubility

WLOGP
3.42
MLOGP
3.03
XLogP3
3
Consensus LogP
3.15
Log S (ESOL)
-4.83
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.4
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.65
Class (SILICOS-IT)
Slightly soluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.8

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3.5

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