CAS RN: 1392136-43-4
Verdinexor (KPT-335)
Product Availability
Choose a grade to view its available package options.
6 package records4 with current stock1 grade group
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20260218 | 100mg | In stock | Shanghai | Inquiry | |
| Batchno.20250225 | 10mg | In stock | Shanghai | Inquiry | |
| Batchno.20250617 | 250mg | Out of stock | Inquiry | ||
| Batchno.20250606 | 25mg | In stock | Shanghai | Inquiry | |
| Batchno.20250209 | 50mg | In stock | Shanghai | Inquiry | |
| Batchno.20260513 | 5mg / 25mg / 50mg | Out of stock | 5-7 business days | Inquiry |
- Product code: starshine_CAS1392136-43-4
- Purity/Analytical Methods: >99.0%
1392136-43-4 / (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide
Basic Information
CAS
1392136-43-4
Multi CAS
No
Molecular Formula
C18H12F6N6O
Molecular Weight
442.300000
Exact Mass
442.097678
SMILES
C1=CC=NC(=C1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4-
InChIKey
OPAKEJZFFCECPN-XQRVVYSFSA-N
Computed Properties
Structural Parameters
Heavy atom count
31
Aromatic heavy atom count
17
Fraction Csp3
0.11
Rotatable bonds
5
H-bond acceptors
6
H-bond donors
2
Molar refractivity
96.79
TPSA
84.73
LogP / Solubility
WLOGP
3.99
MLOGP
3.54
XLogP3
4.1
Consensus LogP
3.88
Log S (ESOL)
-5.17
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.07
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-6.45
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.58
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
2.5
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