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CAS 1354690-24-6 Leniolisib molecular structure lightbox
CAS RN: 1354690-24-6

Leniolisib

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14 package records11 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20251117 100mg In stock Shanghai Inquiry
Batchno.20260311 10mg In stock Shanghai Inquiry
Batchno.20251018 1mg In stock Shanghai Inquiry
Batchno.20251109 250mg In stock Shanghai Inquiry
Batchno.20250222 25mg In stock Shanghai Inquiry
Batchno.20260521 50mg In stock Shanghai Inquiry
Batchno.20250726 5mg In stock Shanghai Inquiry
Batchno.20260329 5mg / 25mg Out of stock 5-7 business days Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260211 100mg In stock Inquiry
Batchno.20260406 10mg In stock Inquiry
Batchno.20250325 1mg In stock Inquiry
Batchno.20250128 25mg Out of stock Inquiry
Batchno.20251004 50mg In stock Inquiry
Batchno.20250123 5mg Out of stock Inquiry
  • Product code: starshine_CAS1354690-24-6
  • Purity/Analytical Methods: >99.0%
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1354690-24-6 / 1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one

Standard CAS: 1354690-24-6 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
1354690-24-6
Multi CAS
No
Molecular Formula
C21H25F3N6O2
Molecular Weight
450.500000
Exact Mass
450.199109
SMILES
CCC(=O)N1CC[C@@H](C1)NC2=NC=NC3=C2CN(CC3)C4=CC(=C(N=C4)OC)C(F)(F)F
InChI
InChI=1S/C21H25F3N6O2/c1-3-18(31)30-6-4-13(10-30)28-19-15-11-29(7-5-17(15)26-12-27-19)14-8-16(21(22,23)24)20(32-2)25-9-14/h8-9,12-13H,3-7,10-11H2,1-2H3,(H,26,27,28)/t13-/m0/s1
InChIKey
MWKYMZXCGYXLPL-ZDUSSCGKSA-N

Computed Properties

Structural Parameters

Heavy atom count
32
Aromatic heavy atom count
12
Fraction Csp3
0.52
Rotatable bonds
5
H-bond acceptors
7
H-bond donors
1
Molar refractivity
111.48
TPSA
83.48

LogP / Solubility

WLOGP
2.88
MLOGP
2.57
XLogP3
2.5
Consensus LogP
2.65
Log S (ESOL)
-4.4
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.34
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.58
Class (SILICOS-IT)
Slightly soluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.42

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3.5

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