CAS RN: 1350884-56-8
LOXO-195
Product Availability
Choose a grade to view its available package options.
1 package records0 with current stock1 grade group
| Batch No. | Package | Availability | Lead Time | Inquiry |
|---|---|---|---|---|
| Batchno.20250616 | 5mg | Out of stock | 8-10 business days | Inquiry |
- Product code: starshine_CAS1350884-56-8
- Purity/Analytical Methods: >99.0%
1350884-56-8 / (6R)-9-fluoro-15-methyl-2,11,16,20,21,24-hexazapentacyclo[16.5.2.02,6.07,12.021,25]pentacosa-1(24),7(12),8,10,18(25),19,22-heptaen-17-one
Basic Information
CAS
1350884-56-8
Multi CAS
No
Molecular Formula
C20H21FN6O
Molecular Weight
380.400000
Exact Mass
380.176087
SMILES
CC1CCC2=C(C=C(C=N2)F)[C@H]3CCCN3C4=NC5=C(C=NN5C=C4)C(=O)N1
InChI
InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12?,17-/m1/s1
InChIKey
OEBIHOVSAMBXIB-RGUGMKFQSA-N
Computed Properties
Structural Parameters
Heavy atom count
28
Aromatic heavy atom count
15
Fraction Csp3
0.4
H-bond acceptors
6
H-bond donors
1
Molar refractivity
101.75
TPSA
75.42
LogP / Solubility
WLOGP
2.67
MLOGP
2.37
XLogP3
2
Consensus LogP
2.35
Log S (ESOL)
-4.28
Class (ESOL)
Slightly soluble
Log S (Ali)
-4.61
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-4.35
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.15
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
8
Customers Also Viewed
-
![CAS 1350885-67-4 3-a]pyrazine molecular structure](data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E)
-
-
N-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine
- CAS RN: 1350913-08-4
- Product Code: SSC-043015
-
2-(1H-pyrazol-1-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- CAS RN: 1350918-90-9
- Product Code: SSC-043016
-
2-Mehtyl-6-[bis(tert-butoxycarbonyl)aMino]-4-chloropyriMidine
- CAS RN: 1350918-95-4
- Product Code: SSC-043017
-
6-chloro-1,2-dihydropyrido[2,3-b]pyrazin-3(4H)-one
- CAS RN: 1350925-20-0
- Product Code: SSC-043019
![CAS 1350885-67-4 3-a]pyrazine molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1350885-67-4.gif)
![CAS 1350918-95-4 2-Mehtyl-6-[bis(tert-butoxycarbonyl)aMino]-4-chloropyriMidine molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/CB62566072(1).gif)
![CAS 1350925-20-0 6-chloro-1,2-dihydropyrido[2,3-b]pyrazin-3(4H)-one molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1350925-20-0.gif)