CAS RN: 1346547-00-9
GSK583
Product Availability
Choose a grade to view its available package options.
11 package records11 with current stock3 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250212 | 10mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20250516 | 1mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20250523 | 25mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20250911 | 2mg | In stock | Shanghai, Wuhan | Inquiry |
| Batchno.20250119 | 50mg | In stock | Shanghai | Inquiry |
| Batchno.20250706 | 5mg | In stock | Shanghai, Wuhan | Inquiry |
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250622 | 1ml | In stock | Inquiry |
- Product code: starshine_CAS1346547-00-9
- Purity/Analytical Methods: >99.0%
1346547-00-9 / 6-tert-butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
Basic Information
CAS
1346547-00-9
Multi CAS
No
Molecular Formula
C20H19FN4O2S
Molecular Weight
398.500000
Exact Mass
398.121275
SMILES
CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
InChI
InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey
XLOGLWKOHPIJLV-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
28
Aromatic heavy atom count
19
Fraction Csp3
0.2
Rotatable bonds
3
H-bond acceptors
5
H-bond donors
2
Molar refractivity
108.02
TPSA
87.74
LogP / Solubility
WLOGP
4.57
MLOGP
4.04
XLogP3
4
Consensus LogP
4.2
Log S (ESOL)
-5.49
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.12
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-6.4
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.91
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3
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