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CAS 1227911-45-6 GSK 2334470 molecular structure lightbox
CAS RN: 1227911-45-6

GSK 2334470

Product Availability

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16 package records14 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20251021 100mg In stock Shanghai Inquiry
Batchno.20250724 10mg In stock Shanghai Inquiry
Batchno.20260613 1mg In stock Shanghai Inquiry
Batchno.20250911 250mg In stock Shanghai Inquiry
Batchno.20251215 25mg Out of stock 5-7 business days Inquiry
Batchno.20251222 25mg In stock Shanghai Inquiry
Batchno.20260429 50mg In stock Shanghai Inquiry
Batchno.20250809 5mg In stock Shanghai, Shandong Inquiry
Batchno.20260421 5mg In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260206 100mg In stock Inquiry
Batchno.20250725 10mg In stock Inquiry
Batchno.20250818 200mg In stock Inquiry
Batchno.20250923 25mg In stock Inquiry
Batchno.20260205 50mg Out of stock Inquiry
Batchno.20260411 5mg In stock Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260606 1ml In stock Inquiry
  • Product code: SSC-026270
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1227911-45-6
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Beijing Inquiry

1227911-45-6 / (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide

Standard CAS: 1227911-45-6 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
1227911-45-6
Multi CAS
No
Molecular Formula
C25H34N8O
Molecular Weight
462.600000
Exact Mass
462.285558
SMILES
C[C@@H]1CC[C@@H](CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5
InChI
InChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1
InChIKey
QLPHOXTXAKOFMU-WBVHZDCISA-N

Computed Properties

Structural Parameters

Heavy atom count
34
Aromatic heavy atom count
15
Fraction Csp3
0.52
Rotatable bonds
5
H-bond acceptors
7
H-bond donors
4
Molar refractivity
135.63
TPSA
124.85

LogP / Solubility

WLOGP
3.7
MLOGP
3.29
XLogP3
3.9
Consensus LogP
3.63
Log S (ESOL)
-5.03
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.02
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-6.34
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.92

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
4.5

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