CAS RN: 1223403-58-4
LOXO-101
Product Availability
Choose a grade to view its available package options.
9 package records8 with current stock1 grade group
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250202 | 100mg | In stock | Shanghai | Inquiry |
| Batchno.20260309 | 10mg | In stock | Shanghai | Inquiry |
| Batchno.20260528 | 1g | In stock | Shanghai | Inquiry |
| Batchno.20260518 | 1mg | In stock | Shanghai | Inquiry |
| Batchno.20260311 | 250mg | In stock | Shanghai | Inquiry |
| Batchno.20250526 | 50mg | In stock | Shanghai | Inquiry |
| Batchno.20250817 | 5g | Out of stock | Inquiry | |
| Batchno.20250803 | 5mg | In stock | Shanghai | Inquiry |
| Batchno.20251006 | 5mg / 25mg / 100mg / 250mg / 1g | Confirm by inquiry | Shanghai, Shandong | Inquiry |
- Product code: starshine_CAS1223403-58-4
- Purity/Analytical Methods: >99.0%
1223403-58-4 / (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
Basic Information
CAS
1223403-58-4
Multi CAS
No
Molecular Formula
C21H22F2N6O2
Molecular Weight
428.400000
Exact Mass
428.177230
SMILES
C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F
InChI
InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
InChIKey
NYNZQNWKBKUAII-KBXCAEBGSA-N
Computed Properties
Structural Parameters
Heavy atom count
31
Aromatic heavy atom count
15
Fraction Csp3
0.38
Rotatable bonds
3
H-bond acceptors
6
H-bond donors
2
Molar refractivity
109.88
TPSA
86
LogP / Solubility
WLOGP
2.95
MLOGP
2.62
XLogP3
1.7
Consensus LogP
2.42
Log S (ESOL)
-4.51
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.2
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.25
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.24
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
4.5
Safety & Transport
GHS Hazard Statements
Not Classified
Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website.
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