CAS RN: 1211443-80-9
LEE011 (hydrochloride)
Product Availability
Choose a grade to view its available package options.
8 package records5 with current stock1 grade group
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20251116 | 100mg | Out of stock | Inquiry | ||
| Batchno.20250420 | 10mg | In stock | Shanghai, Wuhan | Inquiry | |
| Batchno.20250420 | 1mg | In stock | Shanghai, Wuhan | Inquiry | |
| Batchno.20260422 | 250mg | Out of stock | Inquiry | ||
| Batchno.20250528 | 2mg | In stock | Shanghai, Wuhan | Inquiry | |
| Batchno.20250129 | 50mg | In stock | Shanghai | Inquiry | |
| Batchno.20251206 | 5mg | In stock | Shanghai, Wuhan | Inquiry | |
| Batchno.20251113 | 5mg / 10mg / 50mg | Out of stock | 5-7 business days | Inquiry |
- Product code: starshine_CAS1211443-80-9
- Purity/Analytical Methods: >99.0%
1211443-80-9 / 7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide;hydrochloride
Ribociclib hydrochloride | Ribociclib HCl | LEE011 hydrochloride
Basic Information
CAS
1211443-80-9
Multi CAS
No
Molecular Formula
C23H31ClN8O
Molecular Weight
471.000000
Exact Mass
470.230935
SMILES
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5.Cl
InChI
InChI=1S/C23H30N8O.ClH/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1H
InChIKey
JZRSIQPIKASMEV-UHFFFAOYSA-N
Synonyms
Ribociclib hydrochloride
Ribociclib HCl
LEE011 hydrochloride
LEE011 (hydrochloride)
7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride
Computed Properties
Structural Parameters
Heavy atom count
33
Aromatic heavy atom count
15
Fraction Csp3
0.48
Rotatable bonds
5
H-bond acceptors
8
H-bond donors
2
Molar refractivity
132.9
TPSA
91.21
LogP / Solubility
WLOGP
3.22
MLOGP
2.86
XLogP3
3.22
Consensus LogP
3.1
Log S (ESOL)
-4.79
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.75
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.99
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.31
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3.5
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