[email protected]
CAS 1196509-60-0 AZD-7594 molecular structure lightbox
CAS RN: 1196509-60-0

AZD-7594

Product Availability

Choose a grade to view its available package options.

11 package records7 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260411 5mg / 10mg Out of stock 5-7 business days Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260420 100mg Out of stock Inquiry
Batchno.20260614 10mg In stock Shanghai Inquiry
Batchno.20250513 25mg Out of stock Inquiry
Batchno.20251022 50mg Out of stock Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250323 100mg In stock Inquiry
Batchno.20250712 10mg In stock Inquiry
Batchno.20250919 1mg In stock Inquiry
Batchno.20250521 25mg In stock Inquiry
Batchno.20260101 50mg In stock Inquiry
Batchno.20260424 5mg In stock Inquiry
  • Product code: starshine_CAS1196509-60-0
  • Purity/Analytical Methods: >99.0%
GET A QUOTE

1196509-60-0 / 3-[5-[(1S,2R)-2-(2,2-difluoropropanoylamino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]indazol-1-yl]-N-[(3R)-oxolan-3-yl]benzamide

3-[5-[(1R,2S)-2-[(2,2-Difluoro-1-oxopropyl)amino]-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]-1H-indazol-1-yl]-N-(tetrahydro-3-furanyl)benzamide | 3-(5-((1R,2S)-2-((2,2-Difluoro-1-oxopropyl)amino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-(tetrahydro-3-furanyl)benzamide | RefChem:274908

Standard CAS: 1196509-60-0 Multi CAS: Yes
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1196509-60-0
Multi CAS
Yes
Molecular Formula
C32H32F2N4O6
Molecular Weight
606.600000
Exact Mass
606.228991
SMILES
C[C@H]([C@H](C1=CC2=C(C=C1)OCCO2)OC3=CC4=C(C=C3)N(N=C4)C5=CC=CC(=C5)C(=O)N[C@@H]6CCOC6)NC(=O)C(C)(F)F
InChI
InChI=1S/C32H32F2N4O6/c1-19(36-31(40)32(2,33)34)29(20-6-9-27-28(16-20)43-13-12-42-27)44-25-7-8-26-22(15-25)17-35-38(26)24-5-3-4-21(14-24)30(39)37-23-10-11-41-18-23/h3-9,14-17,19,23,29H,10-13,18H2,1-2H3,(H,36,40)(H,37,39)/t19-,23-,29-/m1/s1
InChIKey
ZZWJKLGCDHYVMB-XGBAOLAVSA-N
Synonyms
3-[5-[(1R,2S)-2-[(2,2-Difluoro-1-oxopropyl)amino]-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy]-1H-indazol-1-yl]-N-(tetrahydro-3-furanyl)benzamide 3-(5-((1R,2S)-2-((2,2-Difluoro-1-oxopropyl)amino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-(tetrahydro-3-furanyl)benzamide RefChem:274908 3-(5-((1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-(tetrahydrofuran-3-yl)benzamide SCHEMBL3273974

Computed Properties

Structural Parameters

Heavy atom count
44
Aromatic heavy atom count
21
Fraction Csp3
0.34
Rotatable bonds
9
H-bond acceptors
8
H-bond donors
2
Molar refractivity
156.79
TPSA
112.94

LogP / Solubility

WLOGP
4.6
MLOGP
4.09
XLogP3
4.6
Consensus LogP
4.43
Log S (ESOL)
-6.26
Class (ESOL)
Insoluble
Log S (Ali)
-7.85
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.5
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.16

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
7

Safety & Transport

Pictogram(s)
Health Hazard
Signal
Danger
GHS Hazard Statements
H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
Precautionary Statement Codes
P203, P260, P264, P270, P280, P318, P319, P405, and P501

Customers Also Viewed

Get In Touch

Contact Us