CAS RN: 119577-28-5
7-ETHYL-10-HYDROXYCAMPTOTHECIN
Product Availability
Choose a grade to view its available package options.
8 package records7 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20260613 | 100mg | In stock | Shanghai | Inquiry |
| Batchno.20250505 | 10mg | In stock | Shanghai | Inquiry |
| Batchno.20250910 | 1g | Out of stock | Inquiry | |
| Batchno.20250701 | 250mg | In stock | Shenzhen | Inquiry |
| Batchno.20260226 | 50mg | In stock | Shanghai | Inquiry |
| Batchno.20251224 | 5mg | In stock | Shanghai | Inquiry |
- Product code: starshine_CAS119577-28-5
- Purity/Analytical Methods: >99.0%
119577-28-5 / (19S)-5,19-diethyl-8,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
7-Ethyl-10-hydroxycamptothecin | SN-38 | SN 38 lactone
Basic Information
CAS
119577-28-5
Multi CAS
Yes
Molecular Formula
C22H20N2O5
Molecular Weight
392.400000
Exact Mass
392.137222
SMILES
CCC1=C2C(=C(C=C1)O)C=C3CN4C(=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)C3=N2
InChI
InChI=1S/C22H20N2O5/c1-3-11-5-6-17(25)13-7-12-9-24-16(19(12)23-18(11)13)8-15-14(20(24)26)10-29-21(27)22(15,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey
KWUQFLSWWSXTSZ-QFIPXVFZSA-N
Synonyms
7-Ethyl-10-hydroxycamptothecin
SN-38
SN 38 lactone
SN 38
10-Hydroxy-7-ethylcamptothecin
Computed Properties
Structural Parameters
Heavy atom count
29
Aromatic heavy atom count
16
Fraction Csp3
0.32
Rotatable bonds
2
H-bond acceptors
7
H-bond donors
2
Molar refractivity
105.57
TPSA
101.65
LogP / Solubility
WLOGP
2.35
MLOGP
2.09
XLogP3
1.4
Consensus LogP
1.95
Log S (ESOL)
-4.03
Class (ESOL)
Slightly soluble
Log S (Ali)
-4.47
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-4.4
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-3.45
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
4
