CAS RN: 1195765-45-7
Dabrafenib
Product Availability
Choose a grade to view its available package options.
13 package records13 with current stock3 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20260410 | 100mg | In stock | Shanghai, Shenzhen | Inquiry |
| Batchno.20250617 | 1g | In stock | Shanghai, Shenzhen, Chengdu | Inquiry |
| Batchno.20250721 | 1mg | In stock | Shanghai | Inquiry |
| Batchno.20251119 | 250mg | In stock | Shanghai, Shenzhen, Chengdu | Inquiry |
| Batchno.20260303 | 25g | In stock | Shanghai | Inquiry |
| Batchno.20260622 | 5g | In stock | Shanghai | Inquiry |
| Batchno.20250104 | 5mg | In stock | Shanghai | Inquiry |
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20251228 | 1ml | In stock | Inquiry |
- Product code: starshine_CAS1195765-45-7
- Purity/Analytical Methods: >99.0%
1195765-45-7 / N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Dabrafenib | GSK2118436A | GSK2118436
Basic Information
CAS
1195765-45-7
Multi CAS
Yes
Molecular Formula
C23H20F3N5O2S2
Molecular Weight
519.600000
Exact Mass
519.101052
SMILES
CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
InChI
InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
InChIKey
BFSMGDJOXZAERB-UHFFFAOYSA-N
Synonyms
Dabrafenib
GSK2118436A
GSK2118436
GSK-2118436
QGP4HA4G1B
Computed Properties
Structural Parameters
Heavy atom count
35
Aromatic heavy atom count
23
Fraction Csp3
0.17
Rotatable bonds
5
H-bond acceptors
7
H-bond donors
2
Molar refractivity
128.81
TPSA
110.86
LogP / Solubility
WLOGP
5.36
MLOGP
4.76
XLogP3
4.8
Consensus LogP
4.97
Log S (ESOL)
-6.6
Class (ESOL)
Insoluble
Log S (Ali)
-7.69
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.09
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.08
Drug-likeness / Medicinal Chemistry
Lipinski
No
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.56
Leadlikeness
No
Synthetic Accessibility
3
Safety & Transport
Pictogram(s)
Health Hazard
Environmental Hazard
Signal
Warning
GHS Hazard Statements
H361 (22.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H361fd (77.8%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]
H373 (88.9%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (11.1%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
Precautionary Statement Codes
P203, P260, P273, P280, P318, P319, P391, P405, and P501
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![CAS 1195768-19-4 Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1195768-19-4.gif)
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