![CAS 1190378-57-4 N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1190378-57-4.gif)
CAS RN: 1190378-57-4
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
Product Availability
Choose a grade to view its available package options.
7 package records7 with current stock1 grade group
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250906 | 100mg | In stock | Shanghai | Inquiry |
| Batchno.20260218 | 10mg | In stock | Shanghai | Inquiry |
| Batchno.20251203 | 1mg | In stock | Shanghai | Inquiry |
| Batchno.20250603 | 250mg | In stock | Shanghai | Inquiry |
| Batchno.20251121 | 25mg | In stock | Shanghai | Inquiry |
| Batchno.20260604 | 50mg | In stock | Shanghai | Inquiry |
| Batchno.20250330 | 5mg | In stock | Shanghai | Inquiry |
- Product code: SSC-019480
Historical Factory Record
Historical Supply Reference
This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.
- Pack sizes on record: 0.25g
- Available purity: ≥95%
- Inventory rows with stock: 0
- Bulk packaging: confirmed by inquiry
Reference Pack Sizes
Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.
| Pack Size | Recorded Purity | Available Qty | Ship From | Inquiry |
|---|---|---|---|---|
| 0.25g | ≥95% | 0 Out of Stock | Beijing | Inquiry |
1190378-57-4 / N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
MRT67307 | MRT-67307 | MEY37JZ4XR
Basic Information
CAS
1190378-57-4
Multi CAS
Yes
Molecular Formula
C26H36N6O2
Molecular Weight
464.600000
Exact Mass
464.289974
SMILES
C1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5
InChI
InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)
InChIKey
UKBGBACORPRCGG-UHFFFAOYSA-N
Synonyms
MRT67307
MRT-67307
MEY37JZ4XR
N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
Computed Properties
Structural Parameters
Heavy atom count
34
Aromatic heavy atom count
12
Fraction Csp3
0.58
Rotatable bonds
11
H-bond acceptors
7
H-bond donors
3
Molar refractivity
133.29
TPSA
91.41
LogP / Solubility
WLOGP
3.65
MLOGP
3.24
XLogP3
4
Consensus LogP
3.63
Log S (ESOL)
-4.55
Class (ESOL)
Slightly soluble
Log S (Ali)
-6
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.03
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.96
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
No
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
3.5
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