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CAS 1188910-76-0 CEP-32496 (free base) molecular structure lightbox
CAS RN: 1188910-76-0

CEP-32496 (free base)

Product Availability

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13 package records11 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260420 100mg In stock Shanghai Inquiry
Batchno.20250512 10mg In stock Shanghai Inquiry
Batchno.20260226 1mg / 5mg / 25mg / 100mg Out of stock 5-7 business days Inquiry
Batchno.20260321 250mg In stock Shanghai Inquiry
Batchno.20260114 25mg In stock Shanghai Inquiry
Batchno.20250813 50mg In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260601 100mg In stock Inquiry
Batchno.20260106 10mg In stock Inquiry
Batchno.20260605 1mg In stock Inquiry
Batchno.20250718 25mg In stock Inquiry
Batchno.20251221 50mg Out of stock Inquiry
Batchno.20251122 5mg In stock Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260415 1ml In stock Inquiry
  • Product code: SSC-019110
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1188910-76-0
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Hong Kong Inquiry

1188910-76-0 / 1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea

CEP-32496 | Agerafenib | RXDX-105

Standard CAS: 1188910-76-0 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
1188910-76-0
Multi CAS
Yes
Molecular Formula
C24H22F3N5O5
Molecular Weight
517.500000
Exact Mass
517.157303
SMILES
CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F
InChI
InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33)
InChIKey
DKNUPRMJNUQNHR-UHFFFAOYSA-N
Synonyms
CEP-32496 Agerafenib RXDX-105 78I4VEX88N Rxdx 105

Computed Properties

Structural Parameters

Heavy atom count
37
Aromatic heavy atom count
21
Fraction Csp3
0.25
Rotatable bonds
7
H-bond acceptors
8
H-bond donors
2
Molar refractivity
127.38
TPSA
120.63

LogP / Solubility

WLOGP
5.91
MLOGP
5.24
XLogP3
5
Consensus LogP
5.38
Log S (ESOL)
-6.73
Class (ESOL)
Insoluble
Log S (Ali)
-8.07
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.77
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.68

Drug-likeness / Medicinal Chemistry

Lipinski
No
Ghose
No
Veber
Yes
Egan
No
Muegge
No
Bioavailability score
0.17
Leadlikeness
No
Synthetic Accessibility
4.5

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