CAS RN: 1187990-87-9
MK-8617
Product Availability
Choose a grade to view its available package options.
9 package records3 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250531 | 100mg | Out of stock | Inquiry | ||
| Batchno.20250120 | 10mg | In stock | Shanghai | Inquiry | |
| Batchno.20250724 | 1g | Out of stock | Inquiry | ||
| Batchno.20250706 | 1mg | In stock | Shanghai | Inquiry | |
| Batchno.20260106 | 250mg | Out of stock | Inquiry | ||
| Batchno.20250607 | 25mg | Out of stock | Inquiry | ||
| Batchno.20260326 | 50mg | Out of stock | Inquiry | ||
| Batchno.20260503 | 5mg | In stock | Shanghai | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250611 | 5mg / 25mg / 100mg | Out of stock | 5-7 business days | Inquiry |
- Product code: starshine_CAS1187990-87-9
- Purity/Analytical Methods: >99.0%
1187990-87-9 / N-[bis(4-methoxyphenyl)methyl]-6-oxo-2-pyridazin-3-yl-1H-pyrimidine-5-carboxamide
MK-8617 | 39RRC0G27V | 5-Pyrimidinecarboxamide, N-(bis(4-methoxyphenyl)methyl)-1,6-dihydro-6-oxo-2-(3-pyridazinyl)-
Basic Information
CAS
1187990-87-9
Multi CAS
Yes
Molecular Formula
C24H21N5O4
Molecular Weight
443.500000
Exact Mass
443.159354
SMILES
COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)C3=CN=C(NC3=O)C4=NN=CC=C4
InChI
InChI=1S/C24H21N5O4/c1-32-17-9-5-15(6-10-17)21(16-7-11-18(33-2)12-8-16)27-23(30)19-14-25-22(28-24(19)31)20-4-3-13-26-29-20/h3-14,21H,1-2H3,(H,27,30)(H,25,28,31)
InChIKey
WXLPERVDMILVIF-UHFFFAOYSA-N
Synonyms
MK-8617
39RRC0G27V
5-Pyrimidinecarboxamide, N-(bis(4-methoxyphenyl)methyl)-1,6-dihydro-6-oxo-2-(3-pyridazinyl)-
RefChem:925971
N-(bis(4-methoxyphenyl)methyl)-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide
Computed Properties
Structural Parameters
Heavy atom count
33
Aromatic heavy atom count
24
Fraction Csp3
0.12
Rotatable bonds
7
H-bond acceptors
7
H-bond donors
2
Molar refractivity
121.18
TPSA
119.09
LogP / Solubility
WLOGP
2.76
MLOGP
2.46
XLogP3
2.4
Consensus LogP
2.54
Log S (ESOL)
-4.41
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.19
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.68
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.46
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3
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