[email protected]
CAS 1187431-43-1 GSK1120212 (DMSO solvate) molecular structure lightbox
CAS RN: 1187431-43-1

GSK1120212 (DMSO solvate)

Product Availability

Choose a grade to view its available package options.

6 package records6 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260415 100mg In stock Shanghai Inquiry
Batchno.20250903 1g In stock Shanghai, Shenzhen, Wuhan, Chengdu Inquiry
Batchno.20250609 250mg In stock Shanghai, Shenzhen, Tianjin Inquiry
Batchno.20260512 50mg In stock Shanghai Inquiry
Batchno.20250712 5g In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250710 10mg / 50mg / 250mg / 1g Confirm by inquiry Shanghai, Guangdong, Shandong Inquiry
  • Product code: SSC-018694
GET A QUOTE
Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
Request Bulk Quote

Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1187431-43-1
Pack Size Recorded Purity Available Qty Ship From Inquiry
1g ≥95% 0 Out of Stock Hong Kong Inquiry

1187431-43-1 / N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane

TRAMETINIB DIMETHYL SULFOXIDE | Trametinib DMSO | GSK1120212B

Standard CAS: 1187431-43-1 Multi CAS: Yes
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1187431-43-1
Multi CAS
Yes
Molecular Formula
C28H29FIN5O5S
Molecular Weight
693.500000
Exact Mass
693.091820
SMILES
CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C
InChI
InChI=1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3
InChIKey
OQUFJVRYDFIQBW-UHFFFAOYSA-N
Synonyms
TRAMETINIB DIMETHYL SULFOXIDE Trametinib DMSO GSK1120212B Mekinst UNII-BSB9VJ5TUT

Computed Properties

Structural Parameters

Heavy atom count
41
Aromatic heavy atom count
22
Fraction Csp3
0.29
Rotatable bonds
5
H-bond acceptors
9
H-bond donors
2
Molar refractivity
168.75
TPSA
124.2

LogP / Solubility

WLOGP
3.93
MLOGP
3.52
XLogP3
3.93
Consensus LogP
3.79
Log S (ESOL)
-6.69
Class (ESOL)
Insoluble
Log S (Ali)
-8.09
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.03
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-4.16

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
5

Safety & Transport

Pictogram(s)
Irritant Health Hazard Environmental Hazard
Signal
Danger
GHS Hazard Statements
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] H361 (66.7%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H361d (33.3%): Suspected of damaging the unborn child [Warning Reproductive toxicity] H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H400 (33.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
Precautionary Statement Codes
P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501

Customers Also Viewed

Get In Touch

Contact Us