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CAS 1186486-62-3 LY-2484595 molecular structure lightbox
CAS RN: 1186486-62-3

LY-2484595

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11 package records11 with current stock4 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260612 5mg In stock Shanghai Inquiry
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Batchno.20260624 100mg In stock Inquiry
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Batchno.20250419 5mg In stock Inquiry
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Batchno.20251223 1ml In stock Inquiry
  • Product code: SSC-018529
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1186486-62-3
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.1g ≥95% 0 Out of Stock Beijing Inquiry

1186486-62-3 / 4-[[(5S)-5-[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1-benzazepin-1-yl]methyl]cyclohexane-1-carboxylic acid

Evacetrapib | LY2484595 | Evacetrapib (LY2484595)

Standard CAS: 1186486-62-3 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
1186486-62-3
Multi CAS
Yes
Molecular Formula
C31H36F6N6O2
Molecular Weight
638.600000
Exact Mass
638.280393
SMILES
CC1=CC(=C2C(=C1)[C@H](CCCN2CC3CCC(CC3)C(=O)O)N(CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=NN(N=N5)C)C
InChI
InChI=1S/C31H36F6N6O2/c1-18-11-19(2)27-25(12-18)26(5-4-10-42(27)16-20-6-8-22(9-7-20)28(44)45)43(29-38-40-41(3)39-29)17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h11-15,20,22,26H,4-10,16-17H2,1-3H3,(H,44,45)/t20?,22?,26-/m0/s1
InChIKey
IHIUGIVXARLYHP-UXNJHFGPSA-N
Synonyms
Evacetrapib LY2484595 Evacetrapib (LY2484595) LY-2484595 Evacetrapib [USAN]

Computed Properties

Structural Parameters

Heavy atom count
45
Aromatic heavy atom count
17
Fraction Csp3
0.55
Rotatable bonds
7
H-bond acceptors
7
H-bond donors
1
Molar refractivity
154.61
TPSA
87.38

LogP / Solubility

WLOGP
7.1
MLOGP
6.3
XLogP3
7.7
Consensus LogP
7.03
Log S (ESOL)
-8.09
Class (ESOL)
Insoluble
Log S (Ali)
-9.93
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-10.55
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.57

Drug-likeness / Medicinal Chemistry

Lipinski
No
Ghose
No
Veber
Yes
Egan
No
Muegge
No
Bioavailability score
0.17
Leadlikeness
No
Synthetic Accessibility
5.5

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