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CAS 1184843-57-9 SAR-020106 molecular structure lightbox
CAS RN: 1184843-57-9

SAR-020106

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7 package records7 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20251217 1ml In stock Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260226 100mg In stock Shanghai Inquiry
Batchno.20250924 10mg In stock Shanghai Inquiry
Batchno.20260304 1mg In stock Shanghai Inquiry
Batchno.20250226 25mg In stock Shanghai Inquiry
Batchno.20251218 50mg In stock Shanghai Inquiry
Batchno.20260611 5mg In stock Shanghai Inquiry
  • Product code: SSC-018250
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1184843-57-9
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.1g ≥95% 0 Out of Stock Shenzhen Inquiry

1184843-57-9 / 5-[(8-chloroisoquinolin-3-yl)amino]-3-[(2R)-1-(dimethylamino)propan-2-yl]oxypyrazine-2-carbonitrile

SAR020106;SAR 020106 | SCHEMBL1396948 | CHEMBL1928704

Standard CAS: 1184843-57-9 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
1184843-57-9
Multi CAS
Yes
Molecular Formula
C19H19ClN6O
Molecular Weight
382.800000
Exact Mass
382.130887
SMILES
C[C@H](CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C3C(=C2)C=CC=C3Cl
InChI
InChI=1S/C19H19ClN6O/c1-12(11-26(2)3)27-19-16(8-21)22-10-18(25-19)24-17-7-13-5-4-6-15(20)14(13)9-23-17/h4-7,9-10,12H,11H2,1-3H3,(H,23,24,25)/t12-/m1/s1
InChIKey
SRBJWIBAMIKCMV-GFCCVEGCSA-N
Synonyms
SAR020106;SAR 020106 SCHEMBL1396948 CHEMBL1928704 HMS3741A21 5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile

Computed Properties

Structural Parameters

Heavy atom count
27
Aromatic heavy atom count
16
Fraction Csp3
0.26
Rotatable bonds
6
H-bond acceptors
7
H-bond donors
1
Molar refractivity
105.43
TPSA
86.96

LogP / Solubility

WLOGP
3.62
MLOGP
3.21
XLogP3
3.6
Consensus LogP
3.48
Log S (ESOL)
-4.54
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.31
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.88
Class (SILICOS-IT)
Slightly soluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.48

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3

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