CAS RN: 1174161-86-4
SCR-1481B1
Product Availability
Choose a grade to view its available package options.
1 package records0 with current stock1 grade group
| Batch No. | Package | Availability | Lead Time | Inquiry |
|---|---|---|---|---|
| Batchno.20260611 | 10mg | Out of stock | 5-7 business days | Inquiry |
- Product code: starshine_CAS1174161-86-4
- Purity/Analytical Methods: >99.0%
1174161-86-4 / [3-[[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]carbamoyl]-5-(4-fluorophenyl)-4-oxo-1-pyridinyl]methyl dihydrogen phosphate;2-amino-2-(hydroxymethyl)propane-1,3-diol
SCR-1481B1 | c-Met inhibitor 2 | 2-amino-2-(hydroxymethyl)propane-1,3-diol (3-((4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)carbamoyl)-5-(4-fluorophenyl)-4-oxopyridin-1(4H)-yl)methyl phosphate
Basic Information
CAS
1174161-86-4
Multi CAS
Yes
Molecular Formula
C28H29ClF2N5O10P
Molecular Weight
700.000000
Exact Mass
699.130863
SMILES
C1=CC(=CC=C1C2=CN(C=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)COP(=O)(O)O)F.C(C(CO)(CO)N)O
InChI
InChI=1S/C24H18ClF2N4O7P.C4H11NO3/c25-21-20(7-8-29-23(21)28)38-19-6-5-15(9-18(19)27)30-24(33)17-11-31(12-37-39(34,35)36)10-16(22(17)32)13-1-3-14(26)4-2-13;5-4(1-6,2-7)3-8/h1-11H,12H2,(H2,28,29)(H,30,33)(H2,34,35,36);6-8H,1-3,5H2
InChIKey
SDCKZXWUASKHNF-UHFFFAOYSA-N
Synonyms
SCR-1481B1
c-Met inhibitor 2
2-amino-2-(hydroxymethyl)propane-1,3-diol (3-((4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)carbamoyl)-5-(4-fluorophenyl)-4-oxopyridin-1(4H)-yl)methyl phosphate
C28H29ClF2N5O10P
[3-[[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]carbamoyl]-5-(4-fluorophenyl)-4-oxopyridin-1-yl]methyl dihydrogen phosphate;2-amino-2-(hydroxymethyl)propane-1,3-diol
Computed Properties
Structural Parameters
Heavy atom count
47
Aromatic heavy atom count
24
Fraction Csp3
0.18
Rotatable bonds
11
H-bond acceptors
12
H-bond donors
8
Molar refractivity
165.49
TPSA
252.71
LogP / Solubility
WLOGP
2.2
MLOGP
1.99
XLogP3
2.2
Consensus LogP
2.13
Log S (ESOL)
-5.22
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.89
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.35
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-5.43
Drug-likeness / Medicinal Chemistry
Lipinski
No
Ghose
No
Veber
No
Egan
No
Muegge
No
Bioavailability score
0.17
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
4.5
Customers Also Viewed
-
![CAS 1174193-01-1 (11bR)-2,6-Bis[3,5-bis(trifluoromethyl)phenyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dithiazepine 3,3,5,5-tetraoxide molecular structure](data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%200%200'%3E%3C/svg%3E)
(11bR)-2,6-Bis[3,5-bis(trifluoromethyl)phenyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dithiazepine 3,3,5,5-tetraoxide
- CAS RN: 1174193-01-1
- Product Code: starshine_CAS1174193-01-1
- Purity/Analytical method: >99.0%
-
Benzo[1,2-b:3,4-b’:5,6-b”]trithiophene, 2,5,8-tribromo-
- CAS RN: 1174223-26-7
- Product Code: SSC-017294
-
-
9-(1,3-Dioxolan-2-ylMethyl)-3,9-dihydro-1,3-diMethyl-1H-purine-2,6-dione
- CAS RN: 1174289-18-9
- Product Code: starshine_CAS1174289-18-9
- Purity/Analytical method: >99.0%
-
-
4-ethynyl-1H-pyrrolo[2,3-b]pyridine
- CAS RN: 1174297-28-9
- Product Code: starshine_CAS1174297-28-9
- Purity/Analytical method: >99.0%
![CAS 1174193-01-1 (11bR)-2,6-Bis[3,5-bis(trifluoromethyl)phenyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dithiazepine 3,3,5,5-tetraoxide molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1174193-01-1.gif)
![CAS 1174223-26-7 Benzo[1,2-b:3,4-b’:5,6-b”]trithiophene, 2,5,8-tribromo- molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1174223-26-7.gif)
![CAS 1174297-28-9 4-ethynyl-1H-pyrrolo[2,3-b]pyridine molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/1174297-28-9.gif)