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CAS 1152311-62-0 VX-661 molecular structure lightbox
CAS RN: 1152311-62-0

VX-661

Product Availability

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9 package records9 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250317 100mg In stock Shanghai Inquiry
Batchno.20260216 10mg In stock Shanghai Inquiry
Batchno.20260220 1g In stock Shanghai Inquiry
Batchno.20250503 1mg In stock Shanghai Inquiry
Batchno.20260404 250mg In stock Shanghai Inquiry
Batchno.20260219 25mg In stock Shanghai Inquiry
Batchno.20251022 25mg / 100mg / 250mg Confirm by inquiry Shanghai 5-7 business days Inquiry
Batchno.20250504 5g In stock Shanghai Inquiry
Batchno.20260326 5mg In stock Shanghai, Tianjin Inquiry
  • Product code: SSC-014911
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1152311-62-0
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Shanghai Inquiry

1152311-62-0 / 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide

Tezacaftor | 8RW88Y506K | cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-n-[1-[(2r)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1h-indol-5-yl]-

Standard CAS: 1152311-62-0 Multi CAS: Yes
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1152311-62-0
Multi CAS
Yes
Molecular Formula
C26H27F3N2O6
Molecular Weight
520.500000
Exact Mass
520.182121
SMILES
CC(C)(CO)C1=CC2=CC(=C(C=C2N1C[C@H](CO)O)F)NC(=O)C3(CC3)C4=CC5=C(C=C4)OC(O5)(F)F
InChI
InChI=1S/C26H27F3N2O6/c1-24(2,13-33)22-8-14-7-18(17(27)10-19(14)31(22)11-16(34)12-32)30-23(35)25(5-6-25)15-3-4-20-21(9-15)37-26(28,29)36-20/h3-4,7-10,16,32-34H,5-6,11-13H2,1-2H3,(H,30,35)/t16-/m1/s1
InChIKey
MJUVRTYWUMPBTR-MRXNPFEDSA-N
Synonyms
Tezacaftor 8RW88Y506K cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-n-[1-[(2r)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1h-indol-5-yl]- DTXSID40673070 SYMKEVI COMPONENT TEZACAFTOR

Computed Properties

Structural Parameters

Heavy atom count
37
Aromatic heavy atom count
15
Fraction Csp3
0.42
Rotatable bonds
8
H-bond acceptors
7
H-bond donors
4
Molar refractivity
127.29
TPSA
113.18

LogP / Solubility

WLOGP
3.4
MLOGP
3.03
XLogP3
2.9
Consensus LogP
3.11
Log S (ESOL)
-4.98
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.28
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-6.82
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.48

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
5.5

Safety & Transport

GHS Hazard Statements
Not Classified Reported as not meeting GHS hazard criteria by 2 of 2 companies. For more detailed information, please visit ECHA C&L website.

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