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CAS 1140909-48-3 Cabozantinib Malate molecular structure lightbox
CAS RN: 1140909-48-3

Cabozantinib Malate

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16 package records16 with current stock5 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260223 100mg In stock Inquiry
Batchno.20250423 10mg In stock Inquiry
Batchno.20251103 250mg In stock Inquiry
Batchno.20251013 25mg In stock Inquiry
Batchno.20251116 50mg In stock Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250209 1ml In stock Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250421 100mg / 250mg / 1g / 5g / 25g Confirm by inquiry Shanghai, Shandong 5-7 business days Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20251123 10mg / 50mg / 100mg / 250mg / 1g / 5g Confirm by inquiry Shanghai, Shandong Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20260215 100mg In stock Shanghai, Shenzhen, Tianjin Inquiry
Batchno.20260319 10g In stock Shanghai Inquiry
Batchno.20250718 1g In stock Shanghai, Tianjin Inquiry
Batchno.20260424 1mg In stock Shanghai Inquiry
Batchno.20250827 250mg In stock Shanghai, Tianjin, Wuhan, Chengdu Inquiry
Batchno.20260101 25g In stock Shanghai Inquiry
Batchno.20260429 50mg In stock Shanghai Inquiry
Batchno.20250211 5g In stock Shanghai Inquiry
  • Product code: SSC-013977
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g, 1g, 5g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1140909-48-3
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Shenzhen Inquiry
1g ≥95% 0 Out of Stock Beijing Inquiry
5g ≥95% 0 Out of Stock Shanghai Inquiry

1140909-48-3 / 1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2S)-2-hydroxybutanedioic acid

Cabozantinib S-malate | Cabozantinib malate | cabozantinib (S)-malate

Standard CAS: 1140909-48-3 Multi CAS: Yes
Basic Information Computed Properties Safety & Transport

Basic Information

CAS
1140909-48-3
Multi CAS
Yes
Molecular Formula
C32H30FN3O10
Molecular Weight
635.600000
Exact Mass
635.191522
SMILES
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C([C@@H](C(=O)O)O)C(=O)O
InChI
InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1
InChIKey
HFCFMRYTXDINDK-WNQIDUERSA-N
Synonyms
Cabozantinib S-malate Cabozantinib malate cabozantinib (S)-malate Cabometyx XL184

Computed Properties

Structural Parameters

Heavy atom count
46
Aromatic heavy atom count
22
Fraction Csp3
0.22
Rotatable bonds
11
H-bond acceptors
9
H-bond donors
5
Molar refractivity
162.58
TPSA
193.61

LogP / Solubility

WLOGP
4.45
MLOGP
3.97
XLogP3
4.45
Consensus LogP
4.29
Log S (ESOL)
-6.21
Class (ESOL)
Insoluble
Log S (Ali)
-7.98
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.8
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-3.44

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
No
Egan
No
Muegge
No
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
5.5

Safety & Transport

Pictogram(s)
Irritant Health Hazard
Signal
Danger
GHS Hazard Statements
H302 (98.1%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (94.2%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (92.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (92.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] H360 (96.2%): May damage fertility or the unborn child [Danger Reproductive toxicity]
Precautionary Statement Codes
P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

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