CAS RN: 1140964-99-3
E-7449
Product Availability
Choose a grade to view its available package options.
7 package records7 with current stock1 grade group
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20260214 | 100mg | In stock | Shanghai | Inquiry |
| Batchno.20250620 | 10mg | In stock | Shanghai | Inquiry |
| Batchno.20260617 | 250mg | In stock | Shanghai | Inquiry |
| Batchno.20250113 | 25mg | In stock | Shanghai | Inquiry |
| Batchno.20251207 | 2mg | In stock | Shanghai | Inquiry |
| Batchno.20251019 | 50mg | In stock | Shanghai | Inquiry |
| Batchno.20250407 | 5mg | In stock | Shanghai | Inquiry |
- Product code: starshine_CAS1140964-99-3
- Purity/Analytical Methods: >99.0%
1140964-99-3 / 11-(1,3-dihydroisoindol-2-ylmethyl)-2,3,10,12-tetrazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8,11-pentaen-4-one
Stenoparib | E7449 | E-7449
Basic Information
CAS
1140964-99-3
Multi CAS
Yes
Molecular Formula
C18H15N5O
Molecular Weight
317.300000
Exact Mass
317.127660
SMILES
C1C2=CC=CC=C2CN1CC3=NC4=NNC(=O)C5=C4C(=CC=C5)N3
InChI
InChI=1S/C18H15N5O/c24-18-13-6-3-7-14-16(13)17(21-22-18)20-15(19-14)10-23-8-11-4-1-2-5-12(11)9-23/h1-7H,8-10H2,(H,22,24)(H,19,20,21)
InChIKey
JLFSBHQQXIAQEC-UHFFFAOYSA-N
Synonyms
Stenoparib
E7449
E-7449
Parp inhibitor 2x-121
9X5A2QIA7C
Computed Properties
Structural Parameters
Heavy atom count
24
Aromatic heavy atom count
16
Fraction Csp3
0.17
Rotatable bonds
2
H-bond acceptors
5
H-bond donors
2
Molar refractivity
93.64
TPSA
73.38
LogP / Solubility
WLOGP
2.39
MLOGP
2.12
XLogP3
1.1
Consensus LogP
1.87
Log S (ESOL)
-3.68
Class (ESOL)
Poorly soluble
Log S (Ali)
-3.89
Class (Ali)
Poorly soluble
Log S (SILICOS-IT)
-3.95
Class (SILICOS-IT)
Poorly soluble
ADME
GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-2.96
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
Yes
Synthetic Accessibility
3.5
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