CAS RN: 1092364-38-9
Poziotinib (HM781-36B)
Product Availability
Choose a grade to view its available package options.
8 package records7 with current stock3 grade groups
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250827 | 100mg | In stock | Shanghai, Wuhan, Chengdu | Inquiry | |
| Batchno.20260307 | 10mg | In stock | Shanghai | Inquiry | |
| Batchno.20251217 | 1g | In stock | Shanghai | Inquiry | |
| Batchno.20251119 | 1mg | In stock | Shanghai | Inquiry | |
| Batchno.20250909 | 250mg | In stock | Shanghai | Inquiry | |
| Batchno.20260624 | 5mg | In stock | Shanghai, Tianjin | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250612 | 5mg / 25mg / 100mg | Out of stock | 5-7 business days | Inquiry |
| Batch No. | Package | Availability | Warehouse | Lead Time | Inquiry |
|---|---|---|---|---|---|
| Batchno.20250722 | 1ml | In stock | Inquiry |
- Product code: starshine_CAS1092364-38-9
- Purity/Analytical Methods: >99.0%
1092364-38-9 / 1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
Poziotinib | NOV120101 | NOV-120101
Basic Information
CAS
1092364-38-9
Multi CAS
No
Molecular Formula
C23H21Cl2FN4O3
Molecular Weight
491.300000
Exact Mass
490.097474
SMILES
COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C
InChI
InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
InChIKey
LPFWVDIFUFFKJU-UHFFFAOYSA-N
Synonyms
Poziotinib
NOV120101
NOV-120101
1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one
HM-781-36B
Computed Properties
Structural Parameters
Heavy atom count
33
Aromatic heavy atom count
16
Fraction Csp3
0.26
Rotatable bonds
6
H-bond acceptors
6
H-bond donors
1
Molar refractivity
126.22
TPSA
76.58
LogP / Solubility
WLOGP
5.38
MLOGP
4.77
XLogP3
5.4
Consensus LogP
5.18
Log S (ESOL)
-6.24
Class (ESOL)
Insoluble
Log S (Ali)
-7.48
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-8.04
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.89
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
3
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