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CAS 10416-59-8 N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds] molecular structure lightbox
CAS RN: 10416-59-8

N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds]

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6 package records5 with current stock3 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20251227 100ml In stock Inquiry
Batchno.20250104 2.5L Out of stock Inquiry
Batchno.20250729 25ml In stock Inquiry
Batchno.20250405 500ml In stock Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250604 5ml / 25ml / 100ml / 500ml / 2.5L Confirm by inquiry Shanghai, Shandong, Guangdong, Chongqing, Hebei Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250530 5ml In stock Shanghai Inquiry
  • Product code: ICTB0510
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10416-59-8 / trimethylsilyl (1E)-N-trimethylsilylethanimidate

N,O-Bis(trimethylsilyl)acetamide | Trimethylsilyl N-trimethylsilylacetamidate | R14N49I64O

Standard CAS: 10416-59-8 Multi CAS: Yes
Basic Information Physical Properties Computed Properties Safety & Transport

Basic Information

CAS
10416-59-8
Multi CAS
Yes
Molecular Formula
C8H21NOSi2
Molecular Weight
203.430000
Exact Mass
203.116167
SMILES
C/C(=N\[Si](C)(C)C)/O[Si](C)(C)C
InChI
InChI=1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+
InChIKey
SIOVKLKJSOKLIF-CMDGGOBGSA-N
Synonyms
N,O-Bis(trimethylsilyl)acetamide Trimethylsilyl N-trimethylsilylacetamidate R14N49I64O DTXCID1030074 DTXSID5051525

Physical Properties

Physical Description
Colorless or pale yellow liquid
State
Liquid

Computed Properties

Structural Parameters

Heavy atom count
12
Fraction Csp3
0.88
Rotatable bonds
2
H-bond acceptors
2
Molar refractivity
60.89
TPSA
21.59

LogP / Solubility

WLOGP
3.09
MLOGP
2.72
XLogP3
3.09
Consensus LogP
2.97
Log S (ESOL)
-2.92
Class (ESOL)
Moderately soluble
Log S (Ali)
-3.46
Class (Ali)
Poorly soluble
Log S (SILICOS-IT)
-3.79
Class (SILICOS-IT)
Poorly soluble

ADME

GI absorption
High
BBB permeant
Yes
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-1.77

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
1.5

Safety & Transport

Pictogram(s)
Flammable Corrosive Irritant
Signal
Danger
GHS Hazard Statements
H226 (97.8%): Flammable liquid and vapor [Warning Flammable liquids] H302 (96.7%): Harmful if swallowed [Warning Acute toxicity, oral] H314 (97.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
Precautionary Statement Codes
P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P330, P363, P370+P378, P403+P235, P405, and P501

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