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CAS 1202759-32-7 CNX-774 molecular structure lightbox
CAS RN: 1202759-32-7

CNX-774

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13 package records12 with current stock4 grade groups
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250128 100mg In stock Shanghai Inquiry
Batchno.20250514 10mg In stock Shanghai Inquiry
Batchno.20260318 1g In stock Shanghai Inquiry
Batchno.20260202 1mg In stock Shanghai Inquiry
Batchno.20250617 250mg In stock Shanghai Inquiry
Batchno.20260403 2mg In stock Shanghai Inquiry
Batchno.20260118 50mg In stock Shanghai Inquiry
Batchno.20260324 5mg In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250922 5mg / 10mg / 50mg / 250mg Out of stock 5-7 business days Inquiry
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Batchno.20260120 10mg In stock Inquiry
Batchno.20250913 50mg In stock Inquiry
Batchno.20260420 5mg In stock Inquiry
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20250904 1ml In stock Inquiry
  • Product code: SSC-021121
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 1202759-32-7
Pack Size Recorded Purity Available Qty Ship From Inquiry
1g ≥95% 0 Out of Stock Shenzhen Inquiry

1202759-32-7 / 4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide

CNX-774 | 4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide | 4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide

Standard CAS: 1202759-32-7 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
1202759-32-7
Multi CAS
Yes
Molecular Formula
C26H22FN7O3
Molecular Weight
499.500000
Exact Mass
499.176816
SMILES
CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)F
InChI
InChI=1S/C26H22FN7O3/c1-3-23(35)31-17-5-4-6-18(13-17)32-24-21(27)15-30-26(34-24)33-16-7-9-19(10-8-16)37-20-11-12-29-22(14-20)25(36)28-2/h3-15H,1H2,2H3,(H,28,36)(H,31,35)(H2,30,32,33,34)
InChIKey
VVLHQJDAUIPZFH-UHFFFAOYSA-N
Synonyms
CNX-774 4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide 4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide CHEMBL2216827 CNX774

Computed Properties

Structural Parameters

Heavy atom count
37
Aromatic heavy atom count
24
Fraction Csp3
0.04
Rotatable bonds
9
H-bond acceptors
8
H-bond donors
4
Molar refractivity
137.97
TPSA
130.16

LogP / Solubility

WLOGP
4.77
MLOGP
4.24
XLogP3
3.9
Consensus LogP
4.3
Log S (ESOL)
-5.83
Class (ESOL)
Slightly soluble
Log S (Ali)
-7.1
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.95
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.38

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
4.5

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