CAS RN: 945614-12-0
ARRY-614
Product Availability
Choose a grade to view its available package options.
6 package records5 with current stock2 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20260121 | 100mg | In stock | Shanghai | Inquiry |
| Batchno.20250819 | 250mg | Out of stock | Inquiry | |
| Batchno.20251108 | 25mg | In stock | Shanghai | Inquiry |
| Batchno.20250224 | 50mg | In stock | Shanghai | Inquiry |
| Batchno.20260315 | 5mg / 10mg / 25mg | Confirm by inquiry | Chongqing, Shanghai | Inquiry |
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250127 | 1ml | In stock | Inquiry |
- Product code: starshine_CAS945614-12-0
- Purity/Analytical Methods: >99.0%
945614-12-0 / 1-[3-tert-butyl-1-(4-methylphenyl)pyrazol-5-yl]-3-[[5-fluoro-2-[1-(2-hydroxyethyl)indazol-5-yl]oxyphenyl]methyl]urea
Basic Information
CAS
945614-12-0
Multi CAS
No
Molecular Formula
C31FH33N6O3
Molecular Weight
556.600000
Exact Mass
556.259817
InChI
InChI=1S/C31H33FN6O3/c1-20-5-8-24(9-6-20)38-29(17-28(36-38)31(2,3)4)35-30(40)33-18-22-15-23(32)7-12-27(22)41-25-10-11-26-21(16-25)19-34-37(26)13-14-39/h5-12,15-17,19,39H,13-14,18H2,1-4H3,(H2,33,35,40)
InChIKey
LNMRSSIMGCDUTP-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
41
Aromatic heavy atom count
26
Fraction Csp3
0.26
Rotatable bonds
8
H-bond acceptors
7
H-bond donors
3
Molar refractivity
156.15
TPSA
106.23
LogP / Solubility
WLOGP
6.07
MLOGP
5.39
XLogP3
5.3
Consensus LogP
5.59
Log S (ESOL)
-7.06
Class (ESOL)
Insoluble
Log S (Ali)
-8.51
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-9.28
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.8
Drug-likeness / Medicinal Chemistry
Lipinski
No
Ghose
No
Veber
Yes
Egan
No
Muegge
No
Bioavailability score
0.17
Leadlikeness
No
Synthetic Accessibility
5
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