CAS RN: 935888-69-0

Oprozomib

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Batchno.20260511 100mg Out of stock Inquiry
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Batchno.20250920 1mg In stock Shanghai Inquiry
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Batchno.20260701 5mg / 25mg Out of stock 15 business days Inquiry
  • Product code: starshine_CAS935888-69-0
  • Purity/Analytical Methods: >99.0%
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935888-69-0 / N-[3-methoxy-1-[[3-methoxy-1-[[1-(2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide

Standard CAS: 935888-69-0 Multi CAS: Yes

Basic Information

CAS
935888-69-0
Multi CAS
Yes
Molecular Formula
C25H32N4O7S
Molecular Weight
532.600000
Exact Mass
532.199171
InChI
InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1
InChIKey
SWZXEVABPLUDIO-WSZYKNRRSA-N

Computed Properties

Structural Parameters

Heavy atom count
37
Aromatic heavy atom count
11
Fraction Csp3
0.48
Rotatable bonds
14
H-bond acceptors
9
H-bond donors
3
Molar refractivity
135.23
TPSA
148.25

LogP / Solubility

WLOGP
0.41
MLOGP
0.4
XLogP3
1.1
Consensus LogP
0.64
Log S (ESOL)
-2.7
Class (ESOL)
Moderately soluble
Log S (Ali)
-4.23
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.14
Class (SILICOS-IT)
Slightly soluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-5.68

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
No
Egan
No
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
6

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