CAS RN: 848463-13-8
FGFR inhibitor
Product Availability
Choose a grade to view its available package options.
1 package records0 with current stock1 grade group
| Batch No. | Package | Availability | Lead Time | Inquiry |
|---|---|---|---|---|
| Batchno.20260128 | 10mg / 50mg | Out of stock | 15 business days | Inquiry |
- Product code: starshine_CAS848463-13-8
- Purity/Analytical Methods: >99.0%
848463-13-8 / 2-amino-5-(1-methoxy-2-methylindolizine-3-carbonyl)benzoic acid
Basic Information
CAS
848463-13-8
Multi CAS
No
Molecular Formula
C18H16N2O4
Molecular Weight
324.300000
Exact Mass
324.111007
InChI
InChI=1S/C18H16N2O4/c1-10-15(20-8-4-3-5-14(20)17(10)24-2)16(21)11-6-7-13(19)12(9-11)18(22)23/h3-9H,19H2,1-2H3,(H,22,23)
InChIKey
SNMCWIDCSPHZRD-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
24
Aromatic heavy atom count
15
Fraction Csp3
0.11
Rotatable bonds
4
H-bond acceptors
5
H-bond donors
2
Molar refractivity
89.93
TPSA
94.03
LogP / Solubility
WLOGP
2.77
MLOGP
2.45
XLogP3
3.9
Consensus LogP
3.04
Log S (ESOL)
-3.79
Class (ESOL)
Poorly soluble
Log S (Ali)
-4.22
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-4.55
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-2.73
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
Yes
Synthetic Accessibility
2.5
Customers Also Viewed
-
bis(4-(9H-carbazol-9-yl)phenyl)diphenylsilane
- CAS RN: 848464-60-8
- Product Code: SSC-192529
-
-
Carbamic acid, N-(4-methyl-2-thiazolyl)-, 1,1-dimethylethyl ester
- CAS RN: 848472-44-6
- Product Code: SSC-192531
-
-
3-chloro-4-((6-methylpyridin-3-yl)oxy)aniline
- CAS RN: 848482-82-6
- Product Code: SSC-192534
-
