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CAS 848133-17-5 HKI 357 molecular structure lightbox
CAS RN: 848133-17-5

HKI 357

Product Availability

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7 package records6 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260627 100mg In stock Inquiry
Batchno.20260226 10mg In stock Inquiry
Batchno.20251227 1mg Out of stock Inquiry
Batchno.20260513 25mg In stock Inquiry
Batchno.20250325 50mg In stock Inquiry
Batchno.20251225 5mg In stock Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20251221 10mg / 25mg / 100mg Confirm by inquiry Shanghai Inquiry
  • Product code: SSC-192453
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 848133-17-5
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.1g ≥95% 0 Out of Stock Shanghai Inquiry

848133-17-5 / (E)-N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

Standard CAS: 848133-17-5 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
848133-17-5
Multi CAS
Yes
Molecular Formula
C31H29CLFN5O3
Molecular Weight
574.000000
Exact Mass
573.194296
InChI
InChI=1S/C31H29ClFN5O3/c1-4-40-29-16-26-24(15-27(29)37-30(39)9-6-12-38(2)3)31(21(17-34)18-35-26)36-23-10-11-28(25(32)14-23)41-19-20-7-5-8-22(33)13-20/h5-11,13-16,18H,4,12,19H2,1-3H3,(H,35,36)(H,37,39)/b9-6+
InChIKey
NERXPXBELDBEPZ-RMKNXTFCSA-N

Computed Properties

Structural Parameters

Heavy atom count
41
Aromatic heavy atom count
22
Fraction Csp3
0.19
Rotatable bonds
11
H-bond acceptors
7
H-bond donors
2
Molar refractivity
159.42
TPSA
99.51

LogP / Solubility

WLOGP
6.68
MLOGP
5.92
XLogP3
6
Consensus LogP
6.2
Log S (ESOL)
-7.28
Class (ESOL)
Insoluble
Log S (Ali)
-9.09
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-10.25
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.48

Drug-likeness / Medicinal Chemistry

Lipinski
No
Ghose
No
Veber
No
Egan
No
Muegge
No
Bioavailability score
0.17
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
4.5

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