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CAS 54925-71-2 2′-O-tert-Butyldimethylsilyl-uridine molecular structure lightbox
CAS RN: 54925-71-2

2′-O-tert-Butyldimethylsilyl-uridine

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1 package records0 with current stock1 grade group
Batch No.PackageAvailabilityLead TimeInquiry
Batchno.20251027 1g Out of stock 15 business days Inquiry
  • Product code: LINO929950
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54925-71-2 / 1-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Standard CAS: 54925-71-2 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
54925-71-2
Multi CAS
Yes
Molecular Formula
C15H26N2O6Si
Molecular Weight
358.460000
Exact Mass
358.156013
InChI
InChI=1S/C15H26N2O6Si/c1-15(2,3)24(4,5)23-12-11(20)9(8-18)22-13(12)17-7-6-10(19)16-14(17)21/h6-7,9,11-13,18,20H,8H2,1-5H3,(H,16,19,21)/t9-,11-,12-,13-/m1/s1
InChIKey
AYQZFVZTNUOLCQ-OJAKKHQRSA-N

Computed Properties

Structural Parameters

Heavy atom count
24
Aromatic heavy atom count
6
Fraction Csp3
0.73
Rotatable bonds
4
H-bond acceptors
7
H-bond donors
3
Molar refractivity
90.4
TPSA
113.78

LogP / Solubility

WLOGP
0.18
MLOGP
0.18
XLogP3
0.18
Consensus LogP
0.18
Log S (ESOL)
-2.1
Class (ESOL)
Moderately soluble
Log S (Ali)
-2.63
Class (Ali)
Moderately soluble
Log S (SILICOS-IT)
-2.62
Class (SILICOS-IT)
Moderately soluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
No
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-4.78

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Brenk alerts
1
Leadlikeness
No
Synthetic Accessibility
4.5

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