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CAS 52169-36-5 Glyburide (potassium salt) molecular structure lightbox
CAS RN: 52169-36-5

Glyburide (potassium salt)

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Batchno.20250106 100mg Out of stock 5-7 business days Inquiry
  • Product code: starshine_CAS52169-36-5
  • Purity/Analytical Methods: >99.0%
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52169-36-5 / potassium [4-[2-[(5-chloro-2-methoxybenzoyl)amino]ethyl]phenyl]sulfonyl-(cyclohexylcarbamoyl)azanide

Standard CAS: 52169-36-5 Multi CAS: Yes
Basic Information Computed Properties

Basic Information

CAS
52169-36-5
Multi CAS
Yes
Molecular Formula
C23H27CLKN3O5S
Molecular Weight
532.100000
Exact Mass
531.099701
InChI
InChI=1S/C23H28ClN3O5S.K/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18;/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29);
InChIKey
WUVNANLGKVVVAV-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
34
Aromatic heavy atom count
12
Fraction Csp3
0.39
Rotatable bonds
8
H-bond acceptors
5
H-bond donors
2
Molar refractivity
126.43
TPSA
115.67

LogP / Solubility

WLOGP
1.43
MLOGP
1.3
XLogP3
1.43
Consensus LogP
1.39
Log S (ESOL)
-3.77
Class (ESOL)
Poorly soluble
Log S (Ali)
-4.96
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-5.27
Class (SILICOS-IT)
Slightly soluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-4.95

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
2.5

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