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CAS 496794-70-8 GLI1-Mediated transcription inhibitor molecular structure lightbox
CAS RN: 496794-70-8

GLI1-Mediated transcription inhibitor

Product Availability

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4 package records3 with current stock2 grade groups
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20260619 100mg In stock Shanghai Inquiry
Batchno.20260105 1g Out of stock Inquiry
Batchno.20260523 250mg In stock Shanghai Inquiry
Batch No.PackageAvailabilityWarehouseInquiry
Batchno.20250806 5mg / 10mg Confirm by inquiry Shanghai Inquiry
  • Product code: SSC-155919
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.25g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 496794-70-8
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.25g ≥95% 0 Out of Stock Beijing Inquiry

496794-70-8 / N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide

Standard CAS: 496794-70-8 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
496794-70-8
Multi CAS
No
Molecular Formula
C24H23CLN4O3
Molecular Weight
450.900000
Exact Mass
450.145868
InChI
InChI=1S/C24H23ClN4O3/c1-29(2)16-6-8-21-22(12-16)28-23(27-21)19-11-15(5-7-20(19)25)26-24(30)14-9-17(31-3)13-18(10-14)32-4/h5-13H,1-4H3,(H,26,30)(H,27,28)
InChIKey
UBHJFPVTEATUFS-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
32
Aromatic heavy atom count
21
Fraction Csp3
0.17
Rotatable bonds
6
H-bond acceptors
5
H-bond donors
2
Molar refractivity
128.37
TPSA
79.48

LogP / Solubility

WLOGP
5.22
MLOGP
4.62
XLogP3
4.7
Consensus LogP
4.85
Log S (ESOL)
-6.01
Class (ESOL)
Insoluble
Log S (Ali)
-7.03
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.64
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.77

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3

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