CAS RN: 486424-20-8
AZD-2858
Product Availability
Choose a grade to view its available package options.
10 package records10 with current stock3 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250621 | 100mg | In stock | Shanghai | Inquiry |
| Batchno.20260311 | 10mg | In stock | Shanghai | Inquiry |
| Batchno.20260104 | 250mg | In stock | Shanghai | Inquiry |
| Batchno.20250430 | 25mg | In stock | Shanghai | Inquiry |
| Batchno.20251001 | 50mg | In stock | Shanghai | Inquiry |
| Batchno.20251021 | 5mg | In stock | Shanghai | Inquiry |
| Batchno.20250514 | 5mg / 25mg | Confirm by inquiry | Shanghai | Inquiry |
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250729 | 1ml | In stock | Inquiry |
- Product code: starshine_CAS486424-20-8
- Purity/Analytical Methods: >99.0%
486424-20-8 / 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide
Basic Information
CAS
486424-20-8
Multi CAS
Yes
Molecular Formula
C21H23N7O3S
Molecular Weight
453.500000
Exact Mass
453.158309
InChI
InChI=1S/C21H23N7O3S/c1-27-9-11-28(12-10-27)32(30,31)17-6-4-15(5-7-17)18-14-24-20(22)19(26-18)21(29)25-16-3-2-8-23-13-16/h2-8,13-14H,9-12H2,1H3,(H2,22,24)(H,25,29)
InChIKey
FHCSBLWRGCOVPT-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
32
Aromatic heavy atom count
18
Fraction Csp3
0.24
Rotatable bonds
5
H-bond acceptors
8
H-bond donors
2
Molar refractivity
120.33
TPSA
134.41
LogP / Solubility
WLOGP
1.31
MLOGP
1.18
XLogP3
0.7
Consensus LogP
1.06
Log S (ESOL)
-3.56
Class (ESOL)
Poorly soluble
Log S (Ali)
-4.22
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-4.29
Class (SILICOS-IT)
Slightly soluble
ADME
GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
No
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
No
Log Kp (skin permeation)
-4.56
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
No
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3
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