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CAS 475489-16-8 AVP-AEW541 molecular structure lightbox
CAS RN: 475489-16-8

AVP-AEW541

Product Availability

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9 package records8 with current stock1 grade group
Batch No.PackageAvailabilityWarehouseLead TimeInquiry
Batchno.20251023 100mg In stock Shanghai Inquiry
Batchno.20251109 10mg In stock Shanghai Inquiry
Batchno.20250417 1mg In stock Shanghai Inquiry
Batchno.20251211 1mg / 5mg Out of stock 5-7 business days Inquiry
Batchno.20250306 250mg In stock Shanghai Inquiry
Batchno.20260616 25mg In stock Shanghai Inquiry
Batchno.20251204 2mg In stock Shanghai Inquiry
Batchno.20260205 50mg In stock Shanghai Inquiry
Batchno.20250824 5mg In stock Shanghai Inquiry
  • Product code: SSC-154526
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Historical Factory Record

Historical Supply Reference

This product has historical factory records. Recorded pack sizes and purity can be used as a supply reference, while project-specific availability is confirmed by inquiry.

  • Pack sizes on record: 0.1g
  • Available purity: ≥95%
  • Inventory rows with stock: 0
  • Bulk packaging: confirmed by inquiry
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Reference Pack Sizes

Reference pack sizes are shown below. Final availability, packaging and delivery schedule are confirmed by inquiry.

Recorded sizes, purity and stock details for CAS 475489-16-8
Pack Size Recorded Purity Available Qty Ship From Inquiry
0.1g ≥95% 0 Out of Stock Beijing Inquiry

475489-16-8 / 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine

Standard CAS: 475489-16-8 Multi CAS: No
Basic Information Computed Properties

Basic Information

CAS
475489-16-8
Multi CAS
No
Molecular Formula
C27H29N5O
Molecular Weight
439.600000
Exact Mass
439.237211
InChI
InChI=1S/C27H29N5O/c28-26-25-24(21-8-4-9-23(14-21)33-17-19-6-2-1-3-7-19)16-32(27(25)30-18-29-26)22-12-20(13-22)15-31-10-5-11-31/h1-4,6-9,14,16,18,20,22H,5,10-13,15,17H2,(H2,28,29,30)
InChIKey
AECDBHGVIIRMOI-UHFFFAOYSA-N

Computed Properties

Structural Parameters

Heavy atom count
33
Aromatic heavy atom count
21
Fraction Csp3
0.33
Rotatable bonds
7
H-bond acceptors
6
H-bond donors
1
Molar refractivity
130.97
TPSA
69.2

LogP / Solubility

WLOGP
4.92
MLOGP
4.36
XLogP3
4.2
Consensus LogP
4.49
Log S (ESOL)
-5.67
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.71
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-7.44
Class (SILICOS-IT)
Insoluble

ADME

GI absorption
High
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
Yes
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-1.91

Drug-likeness / Medicinal Chemistry

Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
4

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