CAS RN: 473720-30-8
AMG 487 (S-enantiomer)
Product Availability
Choose a grade to view its available package options.
1 package records0 with current stock1 grade group
| Batch No. | Package | Availability | Lead Time | Inquiry |
|---|---|---|---|---|
| Batchno.20250701 | 2mg / 5mg | Out of stock | 5-7 business days | Inquiry |
- Product code: starshine_CAS473720-30-8
- Purity/Analytical Methods: >99.0%
473720-30-8 / N-[(1S)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide
Basic Information
CAS
473720-30-8
Multi CAS
No
Molecular Formula
C32F3H28N5O4
Molecular Weight
603.600000
Exact Mass
603.209339
InChI
InChI=1S/C32H28F3N5O4/c1-3-43-25-14-10-24(11-15-25)40-30(38-29-27(31(40)42)7-5-17-37-29)21(2)39(20-23-6-4-16-36-19-23)28(41)18-22-8-12-26(13-9-22)44-32(33,34)35/h4-17,19,21H,3,18,20H2,1-2H3/t21-/m0/s1
InChIKey
WQTKNBPCJKRYPA-NRFANRHFSA-N
Computed Properties
Structural Parameters
Heavy atom count
44
Aromatic heavy atom count
28
Fraction Csp3
0.22
Rotatable bonds
10
H-bond acceptors
8
Molar refractivity
156.33
TPSA
99.44
LogP / Solubility
WLOGP
5.81
MLOGP
5.16
XLogP3
5.2
Consensus LogP
5.39
Log S (ESOL)
-7.05
Class (ESOL)
Insoluble
Log S (Ali)
-8.7
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-9.6
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
Low
BBB permeant
No
P-gp substrate
No
CYP1A2 inhibitor
No
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.28
Drug-likeness / Medicinal Chemistry
Lipinski
No
Ghose
No
Veber
Yes
Egan
Yes
Muegge
No
Bioavailability score
0.56
Leadlikeness
No
Synthetic Accessibility
5.5
Customers Also Viewed
-
(R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-2-yl)propylamino)-3,4-dioxocyclobut-1-enylamino)benzamide
- CAS RN: 473727-83-2
- Product Code: starshine_CAS473727-83-2
- Purity/Analytical method: >99.0%
-
-
3-aMino-N-cyclohexyl-2-hydroxy-N-MethylbenzaMide
- CAS RN: 473731-12-3
- Product Code: starshine_CAS473731-12-3
- Purity/Analytical method: >99.0%
-
(RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE
- CAS RN: 473732-59-1
- Product Code: SSC-154288
-
-
![CAS 473732-59-1 (RS)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROPYLAMINE molecular structure](https://starshinechemical.com/wp-content/uploads/2023/05/473732-59-1.gif)
