CAS RN: 468740-43-4
Insulin-like Growth Factor-1 Receptor Inhibitor
Product Availability
Choose a grade to view its available package options.
10 package records10 with current stock3 grade groups
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20250909 | 100mg | In stock | Shanghai, Shenzhen | Inquiry |
| Batchno.20260518 | 1g | In stock | Shanghai | Inquiry |
| Batchno.20250928 | 250mg | In stock | Shanghai, Shenzhen, Tianjin | Inquiry |
| Batchno.20250128 | 25mg | In stock | Shanghai | Inquiry |
| Batchno.20250211 | 50mg | In stock | Shanghai, Shenzhen, Tianjin | Inquiry |
| Batch No. | Package | Availability | Warehouse | Inquiry |
|---|---|---|---|---|
| Batchno.20260624 | 1ml | In stock | Inquiry |
- Product code: starshine_CAS468740-43-4
- Purity/Analytical Methods: >99.0%
468740-43-4 / 4-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-pyridin-2-one
Basic Information
CAS
468740-43-4
Multi CAS
Yes
Molecular Formula
C25H26CLN5O3
Molecular Weight
480.000000
Exact Mass
479.172417
InChI
InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1
InChIKey
ZWVZORIKUNOTCS-OAQYLSRUSA-N
Computed Properties
Structural Parameters
Heavy atom count
34
Aromatic heavy atom count
21
Fraction Csp3
0.28
Rotatable bonds
6
H-bond acceptors
6
H-bond donors
4
Molar refractivity
134.82
TPSA
106.27
LogP / Solubility
WLOGP
3.86
MLOGP
3.43
XLogP3
2.7
Consensus LogP
3.33
Log S (ESOL)
-5.31
Class (ESOL)
Slightly soluble
Log S (Ali)
-6.28
Class (Ali)
Insoluble
Log S (SILICOS-IT)
-6.71
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.91
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
No
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
4
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