CAS RN: 417717-04-5
Lenvatinib Impurity d
Product Availability
Choose a grade to view its available package options.
1 package records0 with current stock1 grade group
| Batch No. | Package | Availability | Lead Time | Inquiry |
|---|---|---|---|---|
| Batchno.20250326 | 10mg | Out of stock | 8-10 business days | Inquiry |
- Product code: starshine_CAS417717-04-5
- Purity/Analytical Methods: >99.0%
417717-04-5 / 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-hydroxyquinoline-6-carboxamide
Basic Information
CAS
417717-04-5
Multi CAS
Yes
Molecular Formula
C20H17CLN4O4
Molecular Weight
412.800000
Exact Mass
412.093833
InChI
InChI=1S/C20H17ClN4O4/c21-14-7-11(3-4-15(14)25-20(28)24-10-1-2-10)29-18-5-6-23-16-9-17(26)13(19(22)27)8-12(16)18/h3-10,26H,1-2H2,(H2,22,27)(H2,24,25,28)
InChIKey
XEZZOIWZFIDBIQ-UHFFFAOYSA-N
Computed Properties
Structural Parameters
Heavy atom count
29
Aromatic heavy atom count
16
Fraction Csp3
0.15
Rotatable bonds
5
H-bond acceptors
5
H-bond donors
4
Molar refractivity
108.63
TPSA
126.57
LogP / Solubility
WLOGP
3.77
MLOGP
3.34
XLogP3
3
Consensus LogP
3.37
Log S (ESOL)
-4.85
Class (ESOL)
Slightly soluble
Log S (Ali)
-5.67
Class (Ali)
Slightly soluble
Log S (SILICOS-IT)
-6.07
Class (SILICOS-IT)
Insoluble
ADME
GI absorption
High
BBB permeant
No
P-gp substrate
Yes
CYP1A2 inhibitor
Yes
CYP2C19 inhibitor
Yes
CYP2C9 inhibitor
No
CYP2D6 inhibitor
Yes
CYP3A4 inhibitor
Yes
Log Kp (skin permeation)
-2.56
Drug-likeness / Medicinal Chemistry
Lipinski
Yes
Ghose
Yes
Veber
Yes
Egan
Yes
Muegge
Yes
Bioavailability score
0.55
Leadlikeness
No
Synthetic Accessibility
3
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